Results 71 to 80 of about 754,428 (266)
An electronics Threshold-Concept Inventory: Assessment in the face of the dependency of concepts
, 2012 The Theory of Threshold Concepts (TCs), first articulated by Land and Meyer in 2003, provides educators in many disciplines with a tool to identify those special ideas that both define the characteristic ways of thinking of expert practitioners, and ...
Scott, Jonathan B. +2 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Determining the Number of Regimes in a Threshold Autoregressive Model Using Smooth Transition Autoregressions [PDF]
In this paper we propose a method for determining the number of regimes in threshold autoregressive models using smooth transition autoregression as a tool.
Strikholm, Birgit, Teräsvirta, Timo
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Non-Linearity between Inflation Rate and GDP Growth in Malaysia [PDF]
This study analyses the relationship between inflation rate and economic growth rate in the period 1970-2005 in Malaysia. A specific question that is addressed in this study is what the threshold inflation rate for Malaysia.
Qaiser Munir, Kasim Mansur
core
Intonation processing in congenital amusia: discrimination, identification and imitation
, 2010 This study investigated whether congenital amusia, a neuro-developmental disorder of musical perception, also has implications for speech intonation processing.
Stewart, Lauren +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Scaling behavior of the conserved transfer threshold process [PDF]
Physical Review E, 2002 6 pages, 8 figures, accepted for publication in Phys.
openaire +3 more sources