Results 111 to 120 of about 1,111,411 (282)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Threshold Digital Signature Scheme with Shared Key Based on GOST R 34.10-2001

open access: yesБезопасность информационных технологий, 2010
This paper presents threshold digital signature scheme with shared secret based on national standard GOST R 34.10-2001 and its signing protocol. This scheme is suitable for any count of participants and threshold value, easy to deploy and can be used for
P. O. Dzhunkovskiy, A. S. Ditenkova
doaj  

A holey fiber based Brillouin laser

open access: yes, 2002
We demonstrate for the first time a Brillouin laser based on a Holey Fiber (HF). Using a simple Fabry-Perot resonator scheme containing a 75m long highly nonlinear HF with an effective area of 2.85µm2 we obtain a threshold of 125mW and a slope efficiency
Belardi, Walter   +5 more
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Do Very High Tax Rates Induce Bunching? Implications for the Design of Income-Contingent Loan Schemes [PDF]

open access: yes
We test whether very high marginal tax rates affect taxpayer behaviour, using a unique policy. Under the Higher Education Contribution Scheme – an income-related university loans scheme in Australia – former students with a debt face a sharp ...
Andrew Leigh, Bruce Chapman
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Anti-frequency-shift packet detection for D2D power-saving communications over Wi-Fi network

open access: yesTongxin xuebao, 2016
An efficient packet detection scheme based on Wi-Fi interface was proposed.It was implemented by employing a novel normalized factor as a denominator in OFDM symbol synchronization-timing metric.Compared to the old-tradition schemes,the proposed scheme ...
Fan YANG, Xi LIANG, Ke-yu LONG, Li JIANG
doaj   +2 more sources

Cross-Domain Data Sharing Scheme Based on Threshold Proxy Re-Encryption

open access: yesInformation
Cross-domain data exchange is an important technical approach for realizing the value of data assets. However, lacking a single trusted root CA across domains, cross-domain schemes often encounter difficulties in authentication, controlled data flow, and
Bingtao Wu   +3 more
doaj   +1 more source

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