Results 121 to 130 of about 256,005 (297)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A Non-repudiable Multi-Proxy Multi-Signature Scheme

open access: yes, 2012
[[abstract]]In this paper, we shall propose a threshold multi-proxy multi-signature scheme with shared verification. In the scheme allows the group of original signers to delegate the signing capability to the designated group of proxy signers ...
黃明祥;Hwang, Min-Shiang
core  

Verifiable special threshold secret sharing scheme based on eigenvalue

open access: yesTongxin xuebao, 2018
Utilizing the characteristic that the characteristic equation of the n-th order matrix have multiple roots,the secret distributor distributes two different sub-keys to each participant,and these two sub-keys satisfy two conditions:linear independent and ...
Yanshuo ZHANG   +4 more
doaj   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Security of signed ELGamal encryption

open access: yes, 2005
Assuming a cryptographically strong cyclic group G of prime order q and a random hash function H, we show that ElGamal encryption with an added Schnorr signature is secure against the adaptive chosen ciphertext attack, in which an attacker can freely use
Jakobsson, Markus, Schnorr, Claus Peter
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Verifiably Encrypted Signature Scheme with Threshold Adjudication [PDF]

open access: yes, 2006
Verifiably encrypted signature is useful in handling the fair exchange problem especially, online contract signing. In this paper, we propose a verifiably encrypted signature scheme using bilinear pairings.
Ashutosh Saxena, M. Choudary Gorantla
core  

Improvement on a Threshold Authenticated Encryption Scheme

open access: yesJournal of Software, 2010
The authenticated encryption scheme allows one signer to generate an authenticated cipher -text so that no one except the designated verifier can recover the message and verify the message. In a (t, n) threshold authenticated encryption scheme, any t or more signers can generate an authenticated encryption for a message and send it to the designated
openaire   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

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