Results 61 to 70 of about 241,347 (258)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A Security Enhanced Generalized Threshold Signcryption Scheme with Deceit Detection

工程科学与技术, 2010
:By analyzing the first generalized threshold signcryption scheme (WCL scheme) and its improved schemes (TJC scheme, etc.), it was found that they can’t resist several attacks such as equation attack and can’t realize threshold designcryption.
Zhang Wenfang, wang Xiaomin, He Dake
doaj  

Anti-interference design of frequency signal acquisition circuit of monitoring substatio

Gong-kuang zidonghua, 2015
The paper analyzed main causes of interference in frequency signal transmission of underground sensors of coal mine, and focused on anti-interference design scheme of frequency signal acquisition circuit of underground monitoring substation.
ZHANG Jiayi
doaj   +1 more source

On QSAR-based cardiotoxicity modeling with the expressiveness-enhanced graph learning model and dual-threshold scheme. [PDF]

Front Physiol, 2023
Wang H, Zhu G, Izu LT, Chen-Izu Y, Ono N, Altaf-Ul-Amin MD, Kanaya S, Huang M.   +7 more
europepmc   +1 more source

A Threshold Signature Scheme Based on TPM

International Journal of Communications, Network and System Sciences, 2011
For the traditional threshold signature mechanism does not considers whether the nodes which generate part signature are trusted and the traditional signature strategy doesn’t do well in resisting internal attacks and external attacks and collusion attacks, so this paper presents a new threshold signature based on Trusted Platform Module (TPM), based ...
Zhi-Hua Zhang, Si-Rong Zhang, Wen-Jin Yu, Jianjun Li, Bei Gong, Wei Jiang   +5 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic-FROST: Schnorr threshold signatures with a flexible committee

Journal of Mathematical Cryptology
Threshold signatures enable any subgroup of predefined cardinality tt out of a committee of nn participants to generate a valid, aggregated signature.
Cimatti Annalisa, De Sclavis Francesco, Galano Giuseppe, Giammusso Sara, Iezzi Michela, Muci Antonio, Nardelli Matteo, Pedicini Marco   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source