Results 71 to 80 of about 1,107,668 (334)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Fuzzy Proximity based Robust Data Hiding Scheme with Interval Threshold [PDF]
, 2022 Prabhash Kumar Singh +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Anti-interference design of frequency signal acquisition circuit of monitoring substatio
Gong-kuang zidonghua, 2015 The paper analyzed main causes of interference in frequency signal transmission of underground sensors of coal mine, and focused on anti-interference design scheme of frequency signal acquisition circuit of underground monitoring substation.
ZHANG Jiayi
doaj +1 more source
Threshold Encryption Scheme based on Cocks' IBE Scheme
The KIPS Transactions:PartC, 2012 Since one of weak points of public crypto-systems is to require the verification of public key, identity based crypto-systems were proposed as an alternative. However, such techniques need a private key generator which can be a single point of failure. To improve such weakness, threshold identity-based crypto-systems were proposed.
Sergey V. Bezzateev, Dae-Youb Kim
openaire +2 more sources
Digital slope-threshold data compressor [PDF]
, 1973 Slope-threshold compression scheme for telemetered video data is efficient, and its principle of operation is as follows: when slope of raw data exceeds threshold decision reference, previous sample is transmitted.
Anderson, T. O.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source