Serine/threonine kinase 33 mediates thrombin-induced interleukin-8 release from human lung epithelial cells in severe asthma [PDF]
Respiratory ResearchInterleukin (IL)-8, also known as chemokine (CXC motif) ligand 8, contributes to the pathogenesis of neutrophilic asthma. Thrombin exacerbates IL-8/CXCL8-mediated inflammatory responses. However, the underlying mechanisms remain unclear.
Wun-Hao Cheng +9 more
doaj +2 more sources
Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma [PDF]
Scientific Reports, 2023 Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo +5 more
doaj +2 more sources
PLoS Computational Biology, 2022 Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot.
Michael A Kelley, Karin Leiderman
doaj +3 more sources
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]
, 2016 Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K. +4 more
core +17 more sources
Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]
, 2017 Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J. +7 more
core +14 more sources
Journal of Genetic Engineering and Biotechnology, 2023 Background Thrombin is the most important enzyme in the hemostatic process by permitting rapid and localized coagulation in case of tissue damage. Camel thrombin is the natural and proper target enzyme for the previously purified camel tick salivary ...
Mahmoud A. Ibrahim, Hassan M. M. Masoud
doaj +1 more source
Negatively charged phospholipids stimulate factor XI activation by thrombin
Thrombosis Update, 2021 Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX.
Farida Omarova +3 more
doaj +1 more source
Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye +9 more
doaj +1 more source
Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. [PDF]
PLoS ONE, 2014 The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC).
Heiko Rühl +8 more
doaj +1 more source