Results 1 to 10 of about 204,893 (358)
Frontiers in Immunology, 2018 BackgroundThe interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory diseases.
Kerstin Göbel +2 more
exaly +3 more sources
PLoS Computational Biology, 2022 Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot.
Michael A Kelley, Karin Leiderman
doaj +3 more sources
Journal of Genetic Engineering and Biotechnology, 2023 Background Thrombin is the most important enzyme in the hemostatic process by permitting rapid and localized coagulation in case of tissue damage. Camel thrombin is the natural and proper target enzyme for the previously purified camel tick salivary ...
Mahmoud A. Ibrahim, Hassan M. M. Masoud
doaj +1 more source
Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
doaj +1 more source
Negatively charged phospholipids stimulate factor XI activation by thrombin
Thrombosis Update, 2021 Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX.
Farida Omarova +3 more
doaj +1 more source
Scientific Reports, 2023 Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo +5 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye +9 more
doaj +1 more source
Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. [PDF]
PLoS ONE, 2014 The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC).
Heiko Rühl +8 more
doaj +1 more source
Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. [PDF]
PLoS ONE, 2016 Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin,
Calvin H Yeh +4 more
doaj +1 more source
Cardiovascular Diabetology, 2018 Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee +4 more
doaj +1 more source