Results 1 to 10 of about 243,553 (260)

Degeneration and regeneration of peripheral nerves: role of thrombin and its receptor PAR-1 [PDF]

, 2017
The peripheral nervous system has a striking regeneration potential and after damage extensive changes in the differentiation state both of the injured neurons and of the Schwann cells are observed.
Artico, M., Ciraci, V., Fabrizi, C., Fumagalli, L., Leone, S., Maras, B., Pompili, E., Schininà, M. E.   +7 more
core  

How we treat bleeding associated with direct oral anticoagulants [PDF]

, 2016
Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the ...
Franchini, Massimo, Liumbruno, Giancarlo M, Marano, Giuseppe, Pupella, Simonetta, VAGLIO, Stefania   +4 more
core   +1 more source

New High-Affinity Thrombin Aptamers for Advancing Coagulation Therapy: Balancing Thrombin Inhibition for Clot Prevention and Effective Bleeding Management with Antidote

Cells, 2023
Thrombin is a key enzyme involved in blood clotting, and its dysregulation can lead to thrombotic diseases such as stroke, myocardial infarction, and deep vein thrombosis.
Mohamad Ammar Ayass, Natalya Griko, Victor Pashkov, Trivendra Tripathi, Jin Zhang, Ramya Ramankutty Nair, Tutku Okyay, Kevin Zhu, Lina Abi-Mosleh   +8 more
doaj   +1 more source

Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Research and Practice in Thrombosis and Haemostasis, 2020
Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond   +2 more
doaj   +1 more source

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis [PDF]

, 2009
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke.
Abtahian, Alexandra Mazharian, Arias-Salgado, Arias-Salgado, Arthur Weiss, Asselin, Auger, Avecilla, Baker, Best, Best, Cheli, Choudhuri, Dhanjal, Dorahy, Dubois, Ezumi, Gibbins, Gibbins, Harper, Hermiston, Holsinger, Jenson Lim, Jing W. Zhu, Jocelyn M. Auger, Kalia, Kato, Klages, Kovalenko, Kralisz, Kristin N. Kornerup, Le Pera, Lin, Lin, Liu, Mangin, McCarty, McNeill, Michael G. Tomlinson, Minuz, Moarefi, Mocsai, Morton, Neena Kalia, Nonne, Obergfell, Palka, Park, Pasquet, Pasquet, Pasquet, Pearce, Poole, Quek, Senis, Snell, Somani, Sorby, Steve G. Thomas, Steve P. Watson, Stuart Ellison, Superti-Furga, Suzuki-Inoue, Suzuki-Inoue, Tarvinder Dhanjal, Tsuboi, Vandendries, Wagner, Watanabe, Watson, Wonerow, Woodside, Xu, Xu, Yamaguchi, Yan Zhao, Yotis A. Senis, Young, Zhang, Zhu   +79 more
core   +2 more sources

Circulating Extracellular Vesicles Are Strongly Associated With Cardiovascular Risk Markers

Frontiers in Cardiovascular Medicine, 2022
BackgroundExtracellular vesicles (EVs) are submicron membrane-bound vesicles released from various cells, which are emerging as a potential novel biomarker in cardiovascular diseases (CVDs) due to their procoagulatory and prothrombotic properties ...
Ruihan Zhou, Esra Bozbas, Keith Allen-Redpath, Parveen Yaqoob   +3 more
doaj   +1 more source

Thrombin activatable fibrinolysis inhibitor como preditor de sangramento no transplante hepático: estudo piloto observacional

Revista Brasileira de Terapia Intensiva
RESUMO Objetivo: Correlacionar os níveis de thrombin activatable fibrinolysis inhibitor no pós-operatório imediato e com 24 horas de pós-operatório com o volume de sangramento tansoperatório.
Wagner Luis Nedel, Edison Moraes Rodrigues Filho, Alessandro Comarú Pasqualotto   +2 more
doaj   +1 more source

Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus

Frontiers in Cellular Neuroscience, 2022
BackgroundStatus epilepticus (SE) leads to memory impairment following a seizure, attributed to long-term potentiation (LTP) reduction. Thrombin, a coagulation factor that activates protease-activated receptor 1 (PAR1) is involved in cognitive impairment
Efrat Shavit-Stein, Efrat Shavit-Stein, Efrat Shavit-Stein, Shani Berkowitz, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Amir Dori, Amir Dori, Nicola Maggio, Nicola Maggio, Nicola Maggio, Nicola Maggio   +14 more
doaj   +1 more source

Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice

Frontiers in Immunology, 2018
Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation after vascular injury, including the immune-mediated injury that occurs after allogeneic ...
Daxin Chen, Ke Li, El-Li Tham, Lin-Lin Wei, Ning Ma, Philippa C. Dodd, Yi Luo, Daniel Kirchhofer, John H. McVey, Anthony Dorling   +9 more
doaj   +1 more source

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay

Frontiers in Pharmacology, 2020
The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders.
Isra Al Zamel, Abdulrasheed Palakkott, Arshida Ashraf, Rabah Iratni, Mohammed Akli Ayoub   +4 more
doaj   +1 more source