Results 1 to 10 of about 283,949 (400)
PURIFICATION OF THROMBIN [PDF]
Journal of General Physiology, 1942 1. Under certain conditions crude prothrombin changes to thrombin without the addition of extraneous activators and in the absence of ionic calcium. 2. Thrombin is soluble in 0.45 saturated ammonium sulfate, whereas crude prothrombin is not. 3.
H. Milstone
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Hierarchy and assortativity as new tools for affinity investigation: the case of the TBA aptamer-ligand complex [PDF]
IEEE transaction on nanobioscience (2017), 2017 Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging.
Alfinito, E., Cataldo, R., Reggiani, L.
arxiv +3 more sources
The nature of thrombin and anti‐thrombin
The Journal of Physiology, 1913 B. J. Collingwood, Michael MacMahon
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PLoS Computational Biology, 2022 Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot.
Michael A Kelley, Karin Leiderman
doaj +2 more sources
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]
, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert +7 more
core +18 more sources
Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]
, 2017 Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J. +7 more
core +14 more sources
Journal of Genetic Engineering and Biotechnology, 2023 Background Thrombin is the most important enzyme in the hemostatic process by permitting rapid and localized coagulation in case of tissue damage. Camel thrombin is the natural and proper target enzyme for the previously purified camel tick salivary ...
Mahmoud A. Ibrahim, Hassan M. M. Masoud
doaj +1 more source
Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
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Scientific Reports, 2023 Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo +5 more
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Frontiers in Pharmacology, 2021 Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye +9 more
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