Results 1 to 10 of about 128,877 (211)
PURIFICATION OF THROMBIN [PDF]
Journal of General Physiology, 1942 1. Under certain conditions crude prothrombin changes to thrombin without the addition of extraneous activators and in the absence of ionic calcium. 2. Thrombin is soluble in 0.45 saturated ammonium sulfate, whereas crude prothrombin is not. 3.
H. Milstone
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The nature of thrombin and anti‐thrombin
The Journal of Physiology, 1913 B. J. Collingwood, Michael MacMahon
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PLoS Computational Biology, 2022 Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot.
Michael A Kelley, Karin Leiderman
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Journal of Genetic Engineering and Biotechnology, 2023 Background Thrombin is the most important enzyme in the hemostatic process by permitting rapid and localized coagulation in case of tissue damage. Camel thrombin is the natural and proper target enzyme for the previously purified camel tick salivary ...
Mahmoud A. Ibrahim, Hassan M. M. Masoud
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Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
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Scientific Reports, 2023 Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo +5 more
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Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. [PDF]
PLoS ONE, 2014 The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC).
Heiko Rühl +8 more
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Frontiers in Pharmacology, 2021 Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye +9 more
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Do conformational changes contribute to the surface plasmon resonance signal? [PDF]
Biosensors and Bioelectronics, In press, pp.115296 (2023), 2023 Surface plasmon resonance (SPR)-based biosensors are widely used instruments for characterizing molecular interactions. In theory the SPR signal depends only on mass changes for interacting molecules of same chemical nature. Whether conformational changes of interacting molecules also contribute to the SPR signal is still a subject of lively debates ...
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Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. [PDF]
PLoS ONE, 2016 Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin,
Calvin H Yeh +4 more
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