Results 101 to 110 of about 308,830 (401)
Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications
Advanced Materials Technologies, EarlyView.This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin +8 more
wiley +1 more source
Nucleic Acids Research, 2012 The G-quadruplex architecture is a peculiar structure adopted by guanine-rich oligonucleotidic sequences, and, in particular, by several aptamers, including the thrombin-binding aptamer (TBA) that has the highest inhibitory activity against human α ...
I. Russo Krauss +5 more
semanticscholar +1 more source
Deregulation of calcium homeostasis in Bcr-Abl-dependent chronic myeloid leukemia [PDF]
Oncotarget, Impact journals, 2018, 2019 Background: Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the bcr-abl chimeric oncogene, encoding a 210 kDa protein with constitutive tyrosine kinase activity. In spite of the efficiency of tyrosine kinase inhibitors (TKI; Imatinib), other strategies are explored to eliminate CML leukemia stem cells, such as ...
arxiv
Frontiers in Immunology, 2018 BackgroundThe interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory diseases.
Kerstin Göbel +5 more
doaj +1 more source
Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry
Research and Practice in Thrombosis and Haemostasis, 2020 Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin +2 more
doaj +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source
Noncompetitive Inhibitor of Thrombin
ChemBioChem, 2009 Two for the price of one: Full length variegin competitively inhibits thrombin in a substrate-like fashion. Upon proteolysis, the cleaved fragment is able to inhibit thrombin noncompetitively; this results in overall prolonged and potent inhibition. This is the first account of a potent and specific classical noncompetitive inhibitor of the thrombin ...
Koh, C.Y. +3 more
openaire +5 more sources
Electrical Microneedles for Wound Treatment
Advanced Science, EarlyView.A review on state‐of‐art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted.
Yu Wang +6 more
wiley +1 more source
Frontiers in Immunology, 2018 Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation after vascular injury, including the immune-mediated injury that occurs after allogeneic ...
Daxin Chen +9 more
doaj +1 more source
Platelet Biochemistry and Morphology after Cryopreservation [PDF]
, 2020 Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle +2 more
core +1 more source