Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury
Advanced Science, EarlyView.The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He +11 more
wiley +1 more source
The Role of Thrombin in Brain Injury After Hemorrhagic and Ischemic Stroke
Translational Stroke Research, 2020 Fenghui Ye +4 more
semanticscholar +1 more source
INVESTIGATION OF ANTICOAGULATION PROPERTIES OF SULFATED GLYCOSAMINOGLYCAN MIMETICS [PDF]
, 2017 INVESTEGATION OF ANTICOAGULATION PROPERTIES OF SULFATED GLYCOSAMINOGLYCAN MIMETICS By Elsamani Ismail Abdelfadiel, MS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University ...
Abdelfadiel, Elsamani I
core +1 more source
The action of thrombin on fibrinogen [PDF]
, 1952 L. Lóránd, W. R. Middlebrook
openalex +1 more source
Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring
Advanced Electronic Materials, EarlyView.Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park +5 more
wiley +1 more source
Conformationally Locked Peptide–DNA Nanostructures for CRISPR‐Amplified Activity‐Based Sensing
Angewandte Chemie, EarlyView.We report a new class of chemical probes, termed cleavable, locked initiator probes (CLIPs). CLIPs are peptide–DNA nanostructures resembling molecular beacons but enable activity‐based CRISPR‐amplified molecular sensing. CLIPs detect various disease‐relevant proteases, yield superior sensitivity compared to commercial probes, and enable the monitoring ...
Dylan M. Snider +6 more
wiley +2 more sources
A FACTOR IN SERUM WHICH ACCELERATES THE CONVERSION OF PROTHROMBIN TO THROMBIN: I. ITS DETERMINATION AND SOME PHYSIOLOGIC AND BIOCHEMICAL PROPERTIES [PDF]
, 1949 André de Vries +4 more
openalex +1 more source
Hydrogel‐Based Smart Materials for Wound Healing and Sensing
Aggregate, EarlyView.The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong +11 more
wiley +1 more source
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source