Results 221 to 230 of about 249,410 (353)

The Effect of Mechanical Loading on Sprouting Angiogenesis from Engineered Macro‐vessel Model

Small Methods, EarlyView.
A stretchable macro‐vessel model embedded in collagen is subjected to distinct mechanical loading profiles to study sprouting angiogenesis. Finite element analysis maps strain distributions, revealing that lateral stretch enhances sprouting and alignment, while longitudinal stretch inhibits it.
Lior Debbi, Oryan Karni Katovitch, Asaf Silverstein, Theodor Fuchs, Christopher S. Chen, Shulamit Levenberg   +5 more
wiley   +1 more source

Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets. [PDF]

Front Vet Sci
Li RHL, Shaverdian M, Chen C, Stuhlmann C, Stern JA, Nguyen N.   +5 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Gel for Diabetic Foot Ulcer. [PDF]

Pharmaceutics
Olszewska A, Egorova O, Gaggia G, Mylona K, Pitchford S, Rickard J, Forbes B.   +6 more
europepmc   +1 more source

Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure

, 2005
Stephen Hanessian, Éric Therrien, Willem A. L. van Otterlo, Malken Bayrakdarian, Ingemar Nilsson, Ola Fjellström, Yafeng Xue   +6 more
openalex   +1 more source

Detection of ‘antiphospholipid’ antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies bindingβ2-glycoprotein I and prothrombin [PDF]

, 2001
Yonghua Sheng, John G. Hanly, Stephen Reddel, S Kouts, Jan Guerin, Takayoshi Koike, Kenji Ichikawa, Allan Sturgess, Steven A. Krilis   +8 more
openalex   +1 more source

A new strategy of construction of porcine myocardial infarction model for preclinical research

VIEW, EarlyView.
This study proposes a strategy based on the anatomical classification of the porcine left coronary artery (LCA) to establish a stable and reproducible myocardial infarction (MI) model for preclinical research. A combination of LCA classification into nine types via angiography, screening of candidate subtypes, and application of a novel embolic ...
Shixing Huang, Haonan Zhang, Jie Jiang, Bei Qian, Yiming Zhong, Xinming Wang, Kai Wang, Jianglin Wang, Xuan Lu, Qiang Zhao, Xiaofeng Ye   +10 more
wiley   +1 more source

Fibrin Monomer in Thrombosis and Haemostasis: A Clinical Biomarker and Beyond. [PDF]

Int J Mol Sci
Guria K, Melnikov I, Shtelmakh V, Avtaeva Y, Okhota S, Saburova O, Kozlov S, Gabbasov Z.   +7 more
europepmc   +1 more source

Glucocorticoid inhibits thrombin-induced expression of platelet-derived growth factor A-chain and heparin-binding epidermal growth factor-like growth factor in human aortic smooth muscle cells.

, 1993
Toru Nakano, Elaine W. Raines, Judith A. Abraham, Fine Wenzel, Shigeki Higashiyama, Michael Klagsbrun, R. Ross   +6 more
openalex   +1 more source

Transforming acute exacerbations of chronic obstructive pulmonary disease (AECOPD) risk assessment: A multi‐algorithm machine learning approach for precise clinical phenotyping

VIEW, EarlyView.
We addressed the clinical need for individualized early identification of AECOPD by analyzing a longitudinal cohort of 878 COPD patients (20072024) and benchmarking 91 algorithms, yielding an interpretable ensemble model (AECOPD‐RS). The model showed strong performance (C‐index 0.815; validation 1/3/5‐year AUCs 0.864/0.865/0.855), with SHAP/VIMP ...
Yiqun Dong, Junyi Shen, Chaofan Fan, Anqi Lin, Peng Luo, Xin Chen   +5 more
wiley   +1 more source