Results 221 to 230 of about 288,586 (288)
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Thrombosis and Haemostasis, 2010
Summary Dabigatran etexilate is an oral, reversible direct thrombin inhibitor that is approved in the EU and several other countries for the prevention of venous thromboembolism after elective hip and knee replacement, and is in advanced clinical ...
J. Ryn +6 more
semanticscholar +1 more source
Summary Dabigatran etexilate is an oral, reversible direct thrombin inhibitor that is approved in the EU and several other countries for the prevention of venous thromboembolism after elective hip and knee replacement, and is in advanced clinical ...
J. Ryn +6 more
semanticscholar +1 more source
Blood Coagulation & Fibrinolysis, 2007
For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Fania Szlam +4 more
openaire +3 more sources
For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Fania Szlam +4 more
openaire +3 more sources
Canadian Journal of Biochemistry and Physiology, 1959
Purified thrombin-C loses its clotting power upon acetylation. The thrombin-E which is produced during the acetylation has approximately twice the proteolytic activity as the original thrombin-C. Evidently amino groups are not necessary to have thrombin-E activity, but if o-acyl groups are also produced the enzyme does not hydrolyze p ...
Ricardo H. Landaburu, Walter H. Seegers
openaire +3 more sources
Purified thrombin-C loses its clotting power upon acetylation. The thrombin-E which is produced during the acetylation has approximately twice the proteolytic activity as the original thrombin-C. Evidently amino groups are not necessary to have thrombin-E activity, but if o-acyl groups are also produced the enzyme does not hydrolyze p ...
Ricardo H. Landaburu, Walter H. Seegers
openaire +3 more sources
Clinical and Experimental Pharmacology and Physiology, 1994
SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
Michael C. Berndt, Peta M. Dennington
openaire +3 more sources
SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
Michael C. Berndt, Peta M. Dennington
openaire +3 more sources
Current Drug Target -Cardiovascular & Hematological Disorders, 2005
L-Mevalonic acid is the distant precursor of cholesterol, in contrast to cholesterol, L-mevalonic acid, its distant precursor gives rise to farnesyl and geranylgeranyl pyrophosphates in relatively few metabolic steps. These isoprenyl pyrophophates covalently conjugate with specific G-proteins and serve as membrane anchors enabling them to carry out ...
Garry X. Shen +5 more
openaire +3 more sources
L-Mevalonic acid is the distant precursor of cholesterol, in contrast to cholesterol, L-mevalonic acid, its distant precursor gives rise to farnesyl and geranylgeranyl pyrophosphates in relatively few metabolic steps. These isoprenyl pyrophophates covalently conjugate with specific G-proteins and serve as membrane anchors enabling them to carry out ...
Garry X. Shen +5 more
openaire +3 more sources
Coagulation and non‐coagulation effects of thrombin
Journal of Thrombosis and Haemostasis, 2016Thrombin is a multifunctional serine protease produced from prothrombin, and is a key regulator in hemostatic and non‐hemostatic processes. It is the main effector protease in primary hemostasis by activating platelets, and plays a key role in secondary ...
J. Posma, J. Posthuma, H. Spronk
semanticscholar +1 more source