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Thrombin as an Anticoagulant [PDF]
, 2011 Thrombosis is the most prevalent cause of fatal diseases in developed countries. An antithrombotic agent that can be administered to patients with severe acute thrombotic diseases without the risk of causing hemorrhage, as experienced with antithrombotic/thrombolytic therapy in the treatment of acute ischemic stroke or systemic anticoagulants like ...
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Seminars in Thrombosis and Hemostasis, 1998
From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
Frederick A. Ofosu +3 more
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From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombosis, coronary thrombosis, stroke ...
Frederick A. Ofosu +3 more
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Biochimica et Biophysica Acta, 1963
Abstract Preparations of bovine thrombin (EC 3.4.4.13) have been separated into various fractions by means of chromatographic methods including gradient-elution chromatography on DEAE-Sephadex A-25, a DEAE derivative of dextran. The specific clotting activity has thereby been increased 5-fold to a value of 256 NIH units/mg dry wt.
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Abstract Preparations of bovine thrombin (EC 3.4.4.13) have been separated into various fractions by means of chromatographic methods including gradient-elution chromatography on DEAE-Sephadex A-25, a DEAE derivative of dextran. The specific clotting activity has thereby been increased 5-fold to a value of 256 NIH units/mg dry wt.
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Specific Activities of Bovine Thrombin and Thrombin Components
Thrombosis and Haemostasis, 1972SummaryBovine thrombins (Gel-T) isolated from bioactivated crude prothrombin, obtained from Holstein, Jersey and Hereford single animal plasmas, occur in two distributions: either T1, T2 and T3 as 1:2:1 (Type I), or T1 and T2 as 1:1, with T3 absent or present to the extent of 5% of total Thrombin (Type II).
R D Rosenberg, D F Waugh
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Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
Blood Coagulation and Fibrinolysis, 2012The objective of the present study was to assess the suitability of an accurate, sensitive, standardized, chronometric blood coagulation test to determine the anticoagulation activity of dabigatran and to quantify concentrations of dabigatran in plasma ...
J. Stangier, M. Feuring
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Thrombin and Thrombin Inhibitors
1998Thrombin is a 37 kDa glycosylated trypsin-like serine protease that has multiple biological functions. It is formed from a precursor protein, the zymogen prothrombin, by a complex of Factor Xa, Va, phospholipid, and calcium (Tracy et al., 1981). Prothrombin is synthesized by the liver and secreted into the blood stream (Fenton, 1986), where it is ...
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Nature, 1946
BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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BARRATT1 found in 1932 that bacteria do not cause the decomposition of thrombin preparations, but rather that this is a chemical process I have shown that the inactivation of thrombin in native blood and in the pure thrombin solution is the same process as that which is caused by an inactivating system in plasma, but which in the preparation is present
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2013
Generation of thrombin has been established as the critical process leading to coagulation in vivo. Indeed, ex vivo markers of thrombin generation in patients have been useful in detecting thrombosis, while many standard global clot-time tests of haemostasis in blood or plasma samples are simple endpoint measures of the potential to generate thrombin ...
Leslie R, Berry, Anthony K C, Chan
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Generation of thrombin has been established as the critical process leading to coagulation in vivo. Indeed, ex vivo markers of thrombin generation in patients have been useful in detecting thrombosis, while many standard global clot-time tests of haemostasis in blood or plasma samples are simple endpoint measures of the potential to generate thrombin ...
Leslie R, Berry, Anthony K C, Chan
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Blood, 2005
AbstractFollowing initiation of coagulation as part of the hemostatic response to injury, thrombin is generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase complex. Thrombin then has multiple roles. The way in which thrombin interacts with its many substrates has been carefully scrutinized in the past decades, but
David A, Lane +2 more
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AbstractFollowing initiation of coagulation as part of the hemostatic response to injury, thrombin is generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase complex. Thrombin then has multiple roles. The way in which thrombin interacts with its many substrates has been carefully scrutinized in the past decades, but
David A, Lane +2 more
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Chest, 2003
When the activities of the coagulation and fibrinolytic cascades are properly regulated, so that fibrin (FN) deposition and removal are properly balanced, the vascular system is protected from catastrophic blood loss at the site of an injury, while its fluidity is ensured elsewhere.
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When the activities of the coagulation and fibrinolytic cascades are properly regulated, so that fibrin (FN) deposition and removal are properly balanced, the vascular system is protected from catastrophic blood loss at the site of an injury, while its fluidity is ensured elsewhere.
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