Results 21 to 30 of about 138,754 (308)
The role of thrombin in early-onset seizures
Frontiers in Cellular Neuroscience, 2023 A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko +3 more
doaj +1 more source
Inhibition of bovine platelets aggregation in response to Hyalomma anatolicum salivary gland proteins/peptides [PDF]
Veterinary World, 2016 Aim: Ticks are obligate ectoparasites that have an impact on wide range of vertebrates and also act as a potential vector for the transmission of tropical theileriosis, babesiosis, etc., causing significant loss to livestock production worldwide.
Surbhi +4 more
doaj +1 more source
Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin
Biomolecules, 2019 Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova +6 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Oral blood coagulation inhibitors and their receptors, such as factor Xa (FXa), thrombin, and the thrombin receptor protease-activated receptor 1 (PAR1), are entered into clinical trials for acute coronary syndrome therapy; however, the results obtained ...
Emiko Shinozawa +2 more
doaj +1 more source
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression
Frontiers in Molecular Biosciences, 2023 Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti ...
Cierra A. Birch +6 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundThrombolytic therapy for acute thrombosis is limited by life‐threatening side effects such as major bleeding and neurotoxicity. New treatment options with enhanced fibrinolytic potential are therefore required.
Thomas Bonnard +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Cells, 2023 Thrombin is a key enzyme involved in blood clotting, and its dysregulation can lead to thrombotic diseases such as stroke, myocardial infarction, and deep vein thrombosis.
Mohamad Ammar Ayass +8 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria +7 more
wiley +1 more source