Haematologica, 2008 Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis +6 more
doaj +1 more source
Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]
PLoS ONE, 2016 BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez +10 more
doaj +1 more source
Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]
, 2017 Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E. +4 more
core +2 more sources
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts [PDF]
, 2005 Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells.
Kurose, Hitoshi +4 more
core +2 more sources
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]
, 2015 BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G +4 more
core +1 more source
Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.
PLoS ONE, 2020 Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura +5 more
doaj +1 more source
Factor Xa or thrombin: Is thrombin a better target? [PDF]
Journal of Thrombosis and Haemostasis, 2007 The limitations of the vitamin K antagonists have prompted the development of new oral anticoagulants that target specific clotting enzymes. Most of the novel agents currently under development target either thrombin or factor Xa. As the final effector of blood coagulation and the most potent platelet agonist, thrombin is a logical target for new oral ...
openaire +3 more sources
Negatively charged phospholipids stimulate factor XI activation by thrombin
Thrombosis Update, 2021 Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX.
Farida Omarova +3 more
doaj
Stimulation of bone growth with thrombin peptide derivatives [PDF]
, 2005 Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to ...
Carney, Darrell H. +4 more
core +2 more sources
Safety of topical thrombins: the ongoing debate
Patient Safety in Surgery, 2009 Until recently, only bovine-derived thrombin was available for use as a stand-alone topical hemostat or as a component of other hemostatic devices. Concerns over a number of case reports of immune-mediated coagulopathies associated with the use of bovine-
Lomax Christopher
doaj +1 more source