Results 21 to 30 of about 128,976 (310)
Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury
Frontiers in Pharmacology, 2020 Traumatic brain injury (TBI) commonly leads to development of seizures, accounting for approximately 20% of newly diagnosed epilepsy. Despite the high clinical significance, the mechanisms underlying the development of posttraumatic seizures (PTS) remain
Marina Ben Shimon +7 more
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Hierarchy and assortativity as new tools for affinity investigation: the case of the TBA aptamer-ligand complex [PDF]
IEEE transaction on nanobioscience (2017), 2017 Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging.
arxiv +1 more source
Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.
PLoS ONE, 2020 Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura +5 more
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Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus
Frontiers in Cellular Neuroscience, 2022 BackgroundStatus epilepticus (SE) leads to memory impairment following a seizure, attributed to long-term potentiation (LTP) reduction. Thrombin, a coagulation factor that activates protease-activated receptor 1 (PAR1) is involved in cognitive impairment
Efrat Shavit-Stein +14 more
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Factor Xa or thrombin: Is thrombin a better target? [PDF]
Journal of Thrombosis and Haemostasis, 2007 The limitations of the vitamin K antagonists have prompted the development of new oral anticoagulants that target specific clotting enzymes. Most of the novel agents currently under development target either thrombin or factor Xa. As the final effector of blood coagulation and the most potent platelet agonist, thrombin is a logical target for new oral ...
openaire +3 more sources
Inhibition of bovine platelets aggregation in response to Hyalomma anatolicum salivary gland proteins/peptides [PDF]
Veterinary World, 2016 Aim: Ticks are obligate ectoparasites that have an impact on wide range of vertebrates and also act as a potential vector for the transmission of tropical theileriosis, babesiosis, etc., causing significant loss to livestock production worldwide.
Surbhi +4 more
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PLoS ONE, 2013 Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early ...
Jenell R Smith +9 more
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Frontiers in Pharmacology, 2020 The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders.
Isra Al Zamel +4 more
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Modeling the microscopic electrical properties of thrombin binding aptamer (TBA) for label-free biosensors [PDF]
, 2016 Aptamers are chemically produced oligonucleotides, able to bind a variety of targets such as drugs, proteins and pathogens with high sensitivity and selectivity. Therefore, aptamers are largely employed for producing label-free biosensors, with significant applications in diagnostics and drug delivery.
arxiv +1 more source
Safety of topical thrombins: the ongoing debate
Patient Safety in Surgery, 2009 Until recently, only bovine-derived thrombin was available for use as a stand-alone topical hemostat or as a component of other hemostatic devices. Concerns over a number of case reports of immune-mediated coagulopathies associated with the use of bovine-
Lomax Christopher
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