Results 21 to 30 of about 322,328 (395)

Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles

Frontiers in Pharmacology, 2021
Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye, Yizhi Zhang, Yihui Huang, Biao Li, Ruhao Cao, Libing Dai, Bin Huang, Pingge Tian, Li Li, Yaling Han   +9 more
doaj   +1 more source

Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. [PDF]

PLoS ONE, 2014
The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC).
Heiko Rühl, Lars Schröder, Jens Müller, Shorena Sukhitashvili, Julia Welz, Walther C Kuhn, Johannes Oldenburg, Christian Rudlowski, Bernd Pötzsch   +8 more
doaj   +1 more source

Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

Journal of Pharmacological Sciences, 2022
Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs)
Akihiro Okamura, Junichiro Miake, Takuya Tomomori, Aiko Takami, Tatsuya Sawano, Masaru Kato, Kazuyoshi Ogura, Daiki Tsujimoto, Shunsuke Kawatani, Kurniawan Priyono Agung, Tomomi Notsu, Ichiro Hisatome, Kazuhiro Yamamoto, Takeshi Imamura   +13 more
doaj   +1 more source

Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. [PDF]

PLoS ONE, 2016
Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin,
Calvin H Yeh, Alan R Stafford, Beverly A Leslie, James C Fredenburgh, Jeffrey I Weitz   +4 more
doaj   +1 more source

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting

Cardiovascular Diabetology, 2018
Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer, Thomas Gremmel   +4 more
doaj   +1 more source

Thrombin-induced platelet aggregation −effect of dabigatran using automated platelet aggregometry−

Platelets, 2020
Dabigatran, a direct oral thrombin inhibitor, has two therapeutic effects: anticoagulation; and antiplatelet activity. In the clinical field, evaluation of the effect of dabigatran on thrombin-induced platelet aggregation is difficult because of fibrin ...
Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Kiyotaka Oi, Yoko Ishigaku, Kazumasa Oura, Shinsuke Narumi, Masahiro Yamamoto, Yasuo Terayama   +10 more
doaj   +1 more source

Thrombin [PDF]

Molecular Aspects of Medicine, 2008
Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensable for cleavage of the anticoagulant protein C.
openaire   +2 more sources

Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems

Biomedicines, 2021
Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant ...
Shani Berkowitz, Joab Chapman, Amir Dori, Shany Guly Gofrit, Nicola Maggio, Efrat Shavit-Stein   +5 more
doaj   +1 more source

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]

, 2017
Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E., Brailoiu, Eugen, Brailoiu, G. Cristina, Shipsky, Megan M., Yan, Guang   +4 more
core   +2 more sources

Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester [PDF]

, 2017
Background: Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown.
Bagot, C.N., Freeman, D.J., Jordan, F., Leishman, E., Onyiaodike, C.C.   +4 more
core   +1 more source