Results 71 to 80 of about 222,382 (202)

Endothelial protease-activated receptor 4: impotent or important?

Frontiers in Cardiovascular Medicine
The protease thrombin, which increases its levels with various pathologies, can signal through the G protein-coupled receptors protease-activated receptors 1 and 4 (PAR1/PAR4). PAR1 is a high-affinity receptor for thrombin, whereas PAR4 is a low-affinity
Rahul Rajala, Rahul Rajala, Rahul Rajala, Courtney T. Griffin, Courtney T. Griffin   +4 more
doaj   +1 more source

Participation of the hypophyseal-adrenal cortex system in thrombin clearance during immobilization stress [PDF]

Thrombin marked with I-131 resulted in a considerable increase of the thrombined clearance rate in healthy male rats during stress caused by an immobilization lasting 30 minutes, and in an increase of thrombin clearance occurred by a combination of ...
Bazazyan, G. G., Kudryashov, B. A., Shapiro, F. B., Uljanov, A. M.   +3 more
core   +1 more source

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Frontiers in Pharmacology, 2019
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury.
Zhiwei Shao, Sheng Tu, Anwen Shao
doaj   +1 more source

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. [PDF]

, 1985
We have previously characterized a monoclonal antibody, S12, that binds only to activated platelets (McEver, R.P., and M.N. Martin, 1984, J. Biol. Chem., 259:9799-9804). It identifies a platelet membrane protein of Mr 140,000, which we have designated as
Bainton, DF, Jacques, YV, McEver, RP, Shuman, MA, Stenberg, PE   +4 more
core   +1 more source

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]

, 2018
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo, Ceunynck, Karen De, Chaudhry, Sharjeel A., Dockendorff, Chris, Fitch-Tewfik, Jennifer L., Flaumenhaft, Robert, Higgins, Sarah J., Ingber, Donald E., Jain, Abhishek, Parikh, Samir M., Peters, Christian G.   +10 more
core   +1 more source

Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells [PDF]

, 2018
Several studies have reported endothelial cell (EC) derivation from human induced pluripotent stem cells (hiPSCs). However, few have explored their functional properties in depth with respect to line-to-line and batch-to-batch variability and how they ...
Freund, Christian, Halaidych, Oleh V., Mummery, Christine L., Orlova, Valeria V., Riminucci, Mara, Salvatori, Daniela C. F., van den Hil, Francijna   +6 more
core   +3 more sources

Experiência inicial com o uso de adesivo tissular contendo trombina para tratamento do pseudo-aneurisma femoral Treatment of femoral pseudoaneurysm with thrombin tissue adhesive: initial experience

Jornal Vascular Brasileiro, 2006
O pseudo-aneurisma (PSA) após cateterização femoral tem sido diagnosticado com regularidade em serviços com grande movimento de intervenções percutâneas, com incidência variando de 0,05 a 6%.
Daniel Mendes Pinto, José Olimpio Dias Júnior, Bernardo Lopes Cançado Fonseca, Rodrigo Daniel Moreialvar, Leonardo Ghizoni Bez, Caetano de Sousa Lopes   +5 more
doaj   +1 more source

The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity

Journal of Lipid Research, 2007
We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200 μM PL) to platelets (2 × 108/ml) was measured after ...
Salam Ibrahim, Catherine Calzada, Valérie Pruneta-Deloche, Michel Lagarde, Gabriel Ponsin   +4 more
doaj   +1 more source

β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock

Biomedicines
β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular endothelial cell (
Michelle Y. McGee, Ololade Ogunsina, Sadia N. Boshra, Xianlong Gao, Matthias Majetschak   +4 more
doaj   +1 more source

Thrombin Production and Human Neutrophil Elastase Sequestration by Modified Cellulosic Dressings and Their Electrokinetic Analysis

Journal of Functional Biomaterials, 2011
Wound healing is a complex series of biochemical and cellular events. Optimally, functional material design addresses the overlapping acute and inflammatory stages of wound healing based on molecular, cellular, and bio-compatibility issues. In this paper
Nicolette Prevost, Judson Vincent Edwards   +1 more
doaj   +1 more source