Results 61 to 70 of about 158,309 (195)

Oxidative stress model of lipopolysaccharide combined with thrombin inducing in broiler chicks

Frontiers in Veterinary Science
Lipopolysaccharides (LPS) are commonly used to construct inflammation models. However, poultry have a certain degree of tolerance to LPS due to the lack of thrombin XI and XII in their bodies. Thrombin activation produces clotting factors that can cleave
Huiyu Shi, Fengyuan Yang, Zeru Peng, Junlong Wu, Qin Wang, Pingfei Qiu, Ruiying Bao, Liangmin Huang, Xiaochun Li, Haiwen Zhang, Xuemei Wang   +10 more
doaj   +1 more source

The Modified Recombinant Proinsulin: A Simple and Efficient Way to Produce Insulin Glargine in E. coli

Research in Molecular Medicine, 2021
Background: Recombinant insulin glargine, a long-acting analog of insulin, is expressed as proinsulin in the host cell and, after purification and refolding steps, is processed to mature insulin by using trypsin and carboxypeptidase B. Because of several
Seyyedeh khadijeh Hosseini oula, Ali Reza Saeedinia, Mehdi Zeinoddini   +2 more
doaj  

Comparative Investigation of Thromboelastometry and Thrombin Generation for Patients Receiving Direct Oral Anticoagulants or Vitamin K Antagonists

Diagnostics
Background. Alterations induced by direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) to thromboelastometry and thrombin generation are not well defined.
Armando Tripodi, Marco Capecchi, Erica Scalambrino, Marigrazia Clerici, Barbara Scimeca, Pasquale Agosti, Paolo Bucciarelli, Andrea Artoni, Flora Peyvandi   +8 more
doaj   +1 more source

Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy

, 2018
Current treatments for ischemic stroke are insufficient. The lack of effective pharmacological approaches can be mainly attributed to the difficulty in overcoming the blood–brain barrier.
Ann T. Chen (5642132), Miao Li (337830), Jie Liu (15128), Xing Guo (103312), Shenqi Zhang (1806178), Kevin N. Sheth (5499287), Pan Zou (5642129), Gang Deng (28267), Zhishu Tang (5642135), Rui Hu (505795), Fengyi Du (4590976), Fuyao Liu (1840072), Jun Liu (42548), Qianxue Chen (1806181), Xingchun Gou (314773), Jiangbing Zhou (2563663), Liang Han (339956)   +16 more
core   +1 more source

Endothelial protease-activated receptor 4: impotent or important?

Frontiers in Cardiovascular Medicine
The protease thrombin, which increases its levels with various pathologies, can signal through the G protein-coupled receptors protease-activated receptors 1 and 4 (PAR1/PAR4). PAR1 is a high-affinity receptor for thrombin, whereas PAR4 is a low-affinity
Rahul Rajala, Rahul Rajala, Rahul Rajala, Courtney T. Griffin, Courtney T. Griffin   +4 more
doaj   +1 more source

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Frontiers in Pharmacology, 2019
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury.
Zhiwei Shao, Sheng Tu, Anwen Shao
doaj   +1 more source

Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]

, 2007
Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana, Suter, Ueli, Kvajo, Mirna, Fayard, Bérengère, Moreno, Eliza, Lino, Maria Maddalena, Brenner, Hans Rudolf, Monard, Denis   +7 more
core   +1 more source

Experiência inicial com o uso de adesivo tissular contendo trombina para tratamento do pseudo-aneurisma femoral Treatment of femoral pseudoaneurysm with thrombin tissue adhesive: initial experience

Jornal Vascular Brasileiro, 2006
O pseudo-aneurisma (PSA) após cateterização femoral tem sido diagnosticado com regularidade em serviços com grande movimento de intervenções percutâneas, com incidência variando de 0,05 a 6%.
Daniel Mendes Pinto, José Olimpio Dias Júnior, Bernardo Lopes Cançado Fonseca, Rodrigo Daniel Moreialvar, Leonardo Ghizoni Bez, Caetano de Sousa Lopes   +5 more
doaj   +1 more source

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

, 2000
The role of the platelet glycoprotein (GP) Ib-V-IX receptor in thrombin activation of platelets has remained controversial although good evidence suggests that blocking this receptor affects platelet responses to this agonist. The mechanism of expression
Dörmann, D, Kehrel, BE, Clemetson, KJ
core  

β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock

Biomedicines
β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular endothelial cell (
Michelle Y. McGee, Ololade Ogunsina, Sadia N. Boshra, Xianlong Gao, Matthias Majetschak   +4 more
doaj   +1 more source