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Molecular dynamics simulations of human α-thrombin in different structural contexts: evidence for an aptamer-guided cooperation between the two exosites

Journal of Biomolecular Structure and Dynamics, 2021
Human α-thrombin (thrombin) is a multifunctional enzyme that plays a pivotal role in the coagulation pathway. Thrombin activity can be effectively modulated by G-quadruplex-based oligonucleotide aptamers that specifically interact with the two positively
Romualdo Troisi, Nicole Balasco, Luigi Vitagliano   +2 more
exaly   +2 more sources

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The influence of the concentration of thrombin on the dynamic viscoelasticity of clotting blood and fibrinogen-thrombin systems

Biorheology, 1971
Measurements of dynamic elastic modulus E ′ and loss modulus E ″ of clotting blood and fibrinogen solutions were carried out. When the blood is collected into a siliconized polyethylene test tube, the saturated value of E ′ is smaller and that of E ″ is larger, and the clotting time is longer than those when the blood is collected into a non ...
M, Kaibara, E, Fukada
openaire   +2 more sources

Dynamic Changes in Thrombin Generation in Abdominal Sepsis in Mice

Shock, 2014
Systemic inflammatory response syndrome and severe infections are associated with major derangements in the coagulation system. The purpose of this study was to examine the dynamic alterations in thrombin generation in abdominal sepsis. Abdominal sepsis was induced by cecal ligation and puncture (CLP) in C57/Bl6 mice. Cecal ligation and puncture caused
Yongzhi, Wang, Oscar O, Braun, Su, Zhang, Lingtao, Luo, Eva, Norström, Henrik, Thorlacius   +5 more
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The effect of thrombin on the dynamic exchange between intraplatelet and extraplatelet fibrinogen

British Journal of Haematology, 1997
We examined the distribution of platelet fibrinogen and the exchange between intra‐ and extra‐platelet fibrinogen in unstimulated and thrombin‐stimulated platelets. In unstimulated platelets 60% of platelet fibrinogen was found in the soluble platelet fraction and 40% in the insoluble one. In platelets activated with thrombin, changes took place in the
V, Vila, V, Martínez-Sales, E, Réganon, J, Aznar   +3 more
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Dynamic fluctuations in blood of thrombin/antithrombin III complex (TAT)

American Journal of Hematology, 1991
AbstractThe dynamic fluctuation of thrombin‐antithrombin III complex (TAT) was studied in blood obtained during the daytime (at 9 AM, noon, 3 PM), during extracorporeal circulation and during the course of disseminated intravascular coagulation (DIC), to certify whether the level of TAT in blood can reflect the generation of thrombin.
Katsumi Deguchi, Mituo Noguchi, Eiichi Yuwasaki, Takurou Endou, Akira Deguchi, Hideo Wada, Seikou Murashima, Masakatu Nishikawa, Shigeru Shirakawa, Kuniyoshi Tanaka, Minoru Kusagawa   +10 more
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Membrane dynamic alterations associated with activation of human platelets by thrombin

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1980
Two fluorescent probes, N-carboxymethylisatoic anhydride, which binds to membrane proteins, and 1,6-diphenyl-1,3,5-hexatriene, a lipophilic label, have been used to follow membrane microenvironmental changes. Activation of human platelets by thrombin resulted in a simultaneous increase in values of fluorescence polarization (P) of both probes during ...
I, Nathan, G, Fleisher, A, Dvilansky, A, Livne, A H, Parola   +4 more
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Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt

Thrombosis Research, 2020
Changes in the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt result in both bleeding and thrombosis. Routine coagulation tests do not accurately predict bleeding risk, as they are not sensitive to changes in anticoagulant factors.
William Beattie, Romy Kremers, Maria Magnusson, Tessa Peters, Bas de Laat, Winita Hardikar, Paul Monagle, Vera Ignjatovic   +7 more
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Dynamic of Thrombin Generation in Patients with Severe Hemophilia A

2008
In hemophilia A, determination of factor VIII activity is used to classify the extent of impaired hemostasis and to estimate bleeding risks of patients. In contrast, the now established assays of thrombin generation (TGA) (1, 2) are not based on a single clotting factor, but are reflecting the action of the total clotting mechanism.
F. Wenzel, H. H. Brackmann, J. Oldenburg
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Electrochemiluminescence bioassay for thrombin based on dynamic assembly of aptamer, thrombin and N-(aminobutyl)-N-(ethylisoluminol) functionalized gold nanoparticles

Electrochimica Acta, 2014
Abstract An electrochemiluminescence (ECL) bioassay was developed for the sensitive and selective detection of thrombin, based on dynamic interaction of aptamer, thrombin and N-(aminobutyl)-N-(ethylisoluminol) (ABEI) functionalized gold nanoparticles (ABEI-AuNPs).
Xiuxia Yu, Hua Cui
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Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

Science Translational Medicine, 2017
A control-oriented dynamical system model of trauma coagulation helps tailor the resuscitation of severely injured patients.
Amor A, Menezes, Ryan F, Vilardi, Adam P, Arkin, Mitchell J, Cohen   +3 more
openaire   +2 more sources