Results 231 to 240 of about 3,246,752 (251)

Dynamic fluctuations in blood of thrombin/antithrombin III complex (TAT)

American Journal of Hematology, 1991
AbstractThe dynamic fluctuation of thrombin‐antithrombin III complex (TAT) was studied in blood obtained during the daytime (at 9 AM, noon, 3 PM), during extracorporeal circulation and during the course of disseminated intravascular coagulation (DIC), to certify whether the level of TAT in blood can reflect the generation of thrombin.
Katsumi Deguchi, Mituo Noguchi, Eiichi Yuwasaki, Takurou Endou, Akira Deguchi, Hideo Wada, Seikou Murashima, Masakatu Nishikawa, Shigeru Shirakawa, Kuniyoshi Tanaka, Minoru Kusagawa   +10 more
openaire   +2 more sources

Dynamic of Thrombin Generation in Patients with Severe Hemophilia A

2008
In hemophilia A, determination of factor VIII activity is used to classify the extent of impaired hemostasis and to estimate bleeding risks of patients. In contrast, the now established assays of thrombin generation (TGA) (1, 2) are not based on a single clotting factor, but are reflecting the action of the total clotting mechanism.
F. Wenzel, H. H. Brackmann, J. Oldenburg
openaire   +1 more source

Membrane dynamic alterations associated with activation of human platelets by thrombin

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1980
Two fluorescent probes, N-carboxymethylisatoic anhydride, which binds to membrane proteins, and 1,6-diphenyl-1,3,5-hexatriene, a lipophilic label, have been used to follow membrane microenvironmental changes. Activation of human platelets by thrombin resulted in a simultaneous increase in values of fluorescence polarization (P) of both probes during ...
I, Nathan, G, Fleisher, A, Dvilansky, A, Livne, A H, Parola   +4 more
openaire   +2 more sources

Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt

Thrombosis Research, 2020
Changes in the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt result in both bleeding and thrombosis. Routine coagulation tests do not accurately predict bleeding risk, as they are not sensitive to changes in anticoagulant factors.
William Beattie, Romy Kremers, Maria Magnusson, Tessa Peters, Bas de Laat, Winita Hardikar, Paul Monagle, Vera Ignjatovic   +7 more
openaire   +2 more sources

Electrochemiluminescence bioassay for thrombin based on dynamic assembly of aptamer, thrombin and N-(aminobutyl)-N-(ethylisoluminol) functionalized gold nanoparticles

Electrochimica Acta, 2014
Abstract An electrochemiluminescence (ECL) bioassay was developed for the sensitive and selective detection of thrombin, based on dynamic interaction of aptamer, thrombin and N-(aminobutyl)-N-(ethylisoluminol) (ABEI) functionalized gold nanoparticles (ABEI-AuNPs).
Xiuxia Yu, Hua Cui
openaire   +1 more source

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

Science Translational Medicine, 2017
A control-oriented dynamical system model of trauma coagulation helps tailor the resuscitation of severely injured patients.
Amor A, Menezes, Ryan F, Vilardi, Adam P, Arkin, Mitchell J, Cohen   +3 more
openaire   +2 more sources

The dynamics of thrombin formation in patients with pulmonary arterial hypertension

Thrombosis Research, 2021
O. Melnichnikova, M. Simakova, O. Moiseeva, I. Nazarova, N. Klyaus, O. Sirotkina, T. Vavilova   +6 more
openaire   +2 more sources

Rapid and automated quantification of the kinetics of thrombin formation using the Thrombin Dynamics Test (TDT)

Journal of Thrombosis and Haemostasis, 2003
A. Calatzis, A. J. Reininger, A. Spannagl, W. Schramm   +3 more
openaire   +1 more source

Structural insights into the activation of blood coagulation factor XI zymogen by thrombin: A computational molecular dynamics study

Biophysical Chemistry, 2022
Divi Venkateswarlu
exaly  

Selectivity of Neutral/Weakly Basic P1 Group Inhibitors of Thrombin and Trypsin by a Molecular Dynamics Study

Chemistry - A European Journal, 2008
Keli Han, GuanFu Duan
exaly