Results 221 to 230 of about 3,246,752 (251)
A three-dimensional shear dependent continuum model of platelet aggregation under flow. [PDF]
PLoS Comput BiolMontgomery D +6 more
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Journal of Biomolecular Structure and Dynamics, 2021 Human α-thrombin (thrombin) is a multifunctional enzyme that plays a pivotal role in the coagulation pathway. Thrombin activity can be effectively modulated by G-quadruplex-based oligonucleotide aptamers that specifically interact with the two positively
Nicole Balasco +2 more
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Thrombin - A Molecular Dynamics Perspective
Mini-Reviews in Medicinal ChemistryAbstract: Thrombin is a crucial enzyme involved in blood coagulation, essential for maintaining circulatory system integrity and preventing excessive bleeding. However, thrombin is also implicated in pathological conditions such as thrombosis and cancer.
Freddie R Salsbury, Jiajie Xiao
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Thrombin allosteric modulation revisited: a molecular dynamics study
Journal of Molecular Modeling, 2009The regulatory properties of thrombin are derived predominantly from its capacity to produce different functional conformations. Functional studies have revealed that two antagonistic thrombin conformations exist in equilibrium: the fast (procoagulant) and slow (anticoagulant) forms.
Hermes Luís Neubauer de Amorim +2 more
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Biorheology, 1971
Measurements of dynamic elastic modulus E ′ and loss modulus E ″ of clotting blood and fibrinogen solutions were carried out. When the blood is collected into a siliconized polyethylene test tube, the saturated value of E ′ is smaller and that of E ″ is larger, and the clotting time is longer than those when the blood is collected into a non ...
M, Kaibara, E, Fukada
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Measurements of dynamic elastic modulus E ′ and loss modulus E ″ of clotting blood and fibrinogen solutions were carried out. When the blood is collected into a siliconized polyethylene test tube, the saturated value of E ′ is smaller and that of E ″ is larger, and the clotting time is longer than those when the blood is collected into a non ...
M, Kaibara, E, Fukada
openaire +2 more sources
Biophysics, 2013
Thrombin is a major component of blood clotting and involved in the formation of a fibrin clot. One of the precursors during thrombin maturation is prethrombin-2, with the presence of Arg363-Ile364 bond between the light and heavy chain of protein, the only distinction from thrombin.
Alexander Veselovsky
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Thrombin is a major component of blood clotting and involved in the formation of a fibrin clot. One of the precursors during thrombin maturation is prethrombin-2, with the presence of Arg363-Ile364 bond between the light and heavy chain of protein, the only distinction from thrombin.
Alexander Veselovsky
exaly +4 more sources
Dynamic Changes in Thrombin Generation in Abdominal Sepsis in Mice
Shock, 2014Systemic inflammatory response syndrome and severe infections are associated with major derangements in the coagulation system. The purpose of this study was to examine the dynamic alterations in thrombin generation in abdominal sepsis. Abdominal sepsis was induced by cecal ligation and puncture (CLP) in C57/Bl6 mice. Cecal ligation and puncture caused
Yongzhi, Wang +5 more
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Dynamics of clot growth induced by thrombin diffusing into nonstirred citrate human plasma
Biochimica Et Biophysica Acta - General Subjects, 1998The dynamics of clot formation was studied in a two-compartment chamber designed to allow free diffusion of thrombin according to its concentration gradient into nonstirred citrate plasma or fibrinogen solution. Fibrin clots in fibrinogen solutions increased progressively until the substrate was depleted.
Elena Sinauridze, F I Ataullakhanov
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Molecular dynamics simulations of thrombin inhibitors at the S' subsites of thrombin.
Drug design and discovery, 1994Molecular dynamics were carried out to simulate binding interactions between S' subsites of thrombin and hirudin-based thrombin inhibitors. These inhibitors include three segments: an active-site segment, N alpha-acetyl-(D-Phe)-Pro-Arg-Pro-; a fibrinogen-recognition exo-site segment, hirudin 55-65; and a 13-atom-long linker.
Yue, S. Y., Konishi, Y.
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The effect of thrombin on the dynamic exchange between intraplatelet and extraplatelet fibrinogen
British Journal of Haematology, 1997We examined the distribution of platelet fibrinogen and the exchange between intra‐ and extra‐platelet fibrinogen in unstimulated and thrombin‐stimulated platelets. In unstimulated platelets 60% of platelet fibrinogen was found in the soluble platelet fraction and 40% in the insoluble one. In platelets activated with thrombin, changes took place in the
V, Vila +3 more
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