Results 131 to 140 of about 47,729 (258)

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Effect of hyperthermic intraperitoneal chemotherapy on thrombin generation and fibrinolysis. [PDF]

Int J Colorectal Dis
Lundbech M, Krag AE, Iversen LH, Brandsborg B, Hvas AM.   +4 more
europepmc   +1 more source

Technical Specification for Hemocompatibility Assessment of Human Mesenchymal Stem Cells

Cell Proliferation, EarlyView.
A comprehensive evaluation of MSC haemocompatibility is a critical prerequisite for ensuring the safety of systemic delivery. A haemocompatibility level of ‘poor’ indicates a high probability of adverse blood reactions when MSCs contact with blood. ABSTRACT ‘Technical specification for haemocompatibility assessment of human mesenchymal stem cells’ is ...
Jialing Liu, Weiyang Liang, Wenjie Xia, Ping Wang, Jie Hao, Tao Na, Sunxing Yan, Yu Zhang, Ka Li, Qiyuan Li, Guangjin Pan, Jun Wei, Qubo Chen, Jiani Cao, Peijun Zhai, Boqiang Fu, Hengjun Gao, Yong Zhang, Lei Wang, Meimei Guo, Shijun Hu, Lijun Zhu, Yang Zhao, Weiqi Zhang, Zhihong Wu, Yifang Ping, Hongling Zhao, Shuaishuai Niu, Tongbiao Zhao, Aijin Ma, Andy Peng Xiang, Xiaoyong Chen   +31 more
wiley   +1 more source

Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms. [PDF]

Res Pract Thromb Haemost
Arisz RA, Bakker B, van den Ham R, Ahmed A, Eikenboom JCJ, Schols SEM, de Maat MPM, SYMPHONY consortium@SYMPHONY_NL.   +7 more
europepmc   +1 more source

Evaluation of thrombin generation in dogs administered clopidogrel. [PDF]

Front Vet Sci, 2023
Rank K, Lynch AM, Ruterbories LK, Li RHL, Ueda Y.   +4 more
europepmc   +1 more source

Cellularity of Routinely Prepared Cell Blocks: Insights From an International Study

Cytopathology, EarlyView.
This study revealed marked variability in the proportion of poorly cellular cell blocks among preparation methods and laboratories, highlighting the need for improved processing and regular monitoring of cell block adequacy. ABSTRACT Objective Formalin‐fixed, paraffin‐embedded (FFPE) cell blocks (CBs) are widely used for processing cytology specimens ...
Irena Srebotnik Kirbis, Ivana Kholova, Heini Huhtala, Margareta Strojan Flezar, Ruben Rodrigues Roque, Heli‐Hakso Mäkinen, Miisa Litmanen, Danijela Vrdoljak‐Mozetič, Suzana Harabajsa, Ekkehard Hewer, Enrica Bresaola, Lia Van Zuylen‐Manders, Pawel Schubert, Maria Praça, Esther Diana Rossi, Peter Karl Bode, Laetitia Lacoste‐Collin, Jessica Barizzi, Vincenzo Fiorentino, Tobias Hedegaard, Sietske van der Meulen, Ute Engel, Iris Timmer, Tugba Taskin Turkmenoglu, Jadranka Vidak, Elena Vigliar, Sonsoles Aso Manso, Jamal Musayev, Güliz A. Barkan, María D. Lozano, Ljube Ivkovski, Bettien van Hemel, Luca Carsana, Clementina Di Tonno, Birgit Weynand, Tania Labiano, Beatrix Cochand‐Priollet   +36 more
wiley   +1 more source

Baseline Thrombin Generation Test Does Not Predict Thrombotic Events in Acute Leukemia: A Monocentric Prospective Study. [PDF]

Mediterr J Hematol Infect Dis
Biglietto M, Mormile R, Bisegna ML, Laganà A, Faccini A, Papa A, Baldacci E, Santoro C, De Propris MS, Chistolini A.   +9 more
europepmc   +1 more source

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Comparative <i>ex vivo</i> analysis of Mim8 in thrombin generation assays triggered by activated factor XI or tissue factor. [PDF]

Res Pract Thromb Haemost
Ong Clausen WH, Latendorf T, Stehr R, Ezban M, Lund J.   +4 more
europepmc   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source