Results 281 to 290 of about 3,896,793 (331)
Thrombin generation and venous thromboembolism
Hämostaseologie, 2008 SummaryVenous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to risk of recurrence is unknown, and existence of thus far unknown risk factors must be considered. A
S. Eichinger
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Improvements in the Thrombin Generation Test
Thrombosis and Haemostasis, 1960 SummaryThe influence of glass contact on the thrombin generation test was demonstrated and a modified method described.Nearly all prothrombin had been converted to thrombin before the thrombin concentration reached its maximum.
Preben Ollendorff
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Thrombin Generation by Valproate [PDF]
, 2019 Pathological plasmatic thrombin generation can lead to many complications such as thrombotic/atherosclerotic diseases. The contact phase of blood coagulation can be triggered by low plasma concentrations of lipophilic or negatively charged groups. There are two main proteases that can start the whole intrinsic coagulation cascade: activated factor 12 ...
Mohrez, Morad
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Shock, 2021
Thrombin is the central coagulation enzyme that catalyzes the conversion of fibrinogen to form insoluble fibrin blood clots. In vivo, thrombin production results from the concerted effort of plasma enzymatic reactions with essential contributions from ...
J. Cardenas
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Thrombin is the central coagulation enzyme that catalyzes the conversion of fibrinogen to form insoluble fibrin blood clots. In vivo, thrombin production results from the concerted effort of plasma enzymatic reactions with essential contributions from ...
J. Cardenas
semanticscholar +1 more source
International Journal of Laboratory Hematology, 2020
Patients with COVID‐19 are known to have a coagulopathy with a thrombosis risk. It is unknown whether this is due to a generalized humoral prothrombotic state or endothelial factors such as inflammation and dysfunction.
D. White +13 more
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Patients with COVID‐19 are known to have a coagulopathy with a thrombosis risk. It is unknown whether this is due to a generalized humoral prothrombotic state or endothelial factors such as inflammation and dysfunction.
D. White +13 more
semanticscholar +1 more source
Journal of Hepatology, 2019
BACKGROUND AND AIMS The efficacy of fresh frozen plasma (FFP) transfusion in enhancing thrombin generation in patients with cirrhosis and impaired conventional coagulation tests has not been sufficiently explored.
A. B. Rassi +7 more
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BACKGROUND AND AIMS The efficacy of fresh frozen plasma (FFP) transfusion in enhancing thrombin generation in patients with cirrhosis and impaired conventional coagulation tests has not been sufficiently explored.
A. B. Rassi +7 more
semanticscholar +1 more source
Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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Thrombin Generation and the Pathogenesis of Cancer
Seminars in Thrombosis and Hemostasis, 2006Advanced cancer is associated with a hypercoagulable state that is triggered by tissue factor (TF). TF-initiated thrombin generation is crucial for metastasis through fibrin and platelet deposition, as well as thrombin-dependent protease-activated receptor (PAR) 1 signaling. Surprisingly, PAR2, which is not cleaved by thrombin, appears to cosignal with
Wolfram, Ruf, Barbara M, Mueller
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Thrombin generation: phenotypic quantitation
Journal of Thrombosis and Haemostasis, 2004An individual's ability to generate thrombin following tissue factor stimulus was evaluated in 13 healthy male donors in a 6-month study. Thrombin generation in whole blood collected by phlebotomy, contact pathway suppressed by the presence of 100 micro g mL-1 corn trypsin inhibitor, was initiated by the addition of 5 pm tissue factor/10 nm ...
K E, Brummel-Ziedins +2 more
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Thrombosis Research, 2019
BACKGROUND Thrombin generation, thrombin-antithrombin complex (TAT) levels, and prothrombin fragment 1+2 (F1+2) have shown potential as biomarkers of thromboembolic risk.
Mikkel Lundbech +3 more
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BACKGROUND Thrombin generation, thrombin-antithrombin complex (TAT) levels, and prothrombin fragment 1+2 (F1+2) have shown potential as biomarkers of thromboembolic risk.
Mikkel Lundbech +3 more
semanticscholar +1 more source