Results 301 to 310 of about 100,897 (348)
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Thrombin generation and atherosclerosis
Journal of Thrombosis and Thrombolysis, 2013Atherosclerosis is a major cause of mortality worldwide. The important role inflammation plays in atherosclerosis is evident through the participation of inflammatory cells in the development and progression of the disease. Thrombin is the central protease of the coagulation cascade, involved in the formation of a hemostatic plug to avoid severe ...
Kalz, Jana +2 more
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Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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Thrombin Potential and Thrombin Generation After Exhaustive Exercise
International Journal of Sports Medicine, 2002Exhaustive exercise leads to an activation of blood coagulation, but the implications of this activation are still unclear. The aim of this study was to investigate if a hypercoagulant stage exists after exhaustive treadmill- or cycle exercise; intrinsic and extrinsic endogenous thrombin potential (ETP) were measured by using the method of Hemker et al.
T, Hilberg +4 more
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La Revue de medecine interne, 2016
Thrombin is a key enzyme of the coagulation cascade, having both pro- and anticoagulant functions. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Estimation of an individual's potential to generate thrombin may correlate more closely with a hyper- or hypo-coagulable phenotype, compared to traditional
O, Espitia, M, Fouassier
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Thrombin is a key enzyme of the coagulation cascade, having both pro- and anticoagulant functions. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Estimation of an individual's potential to generate thrombin may correlate more closely with a hyper- or hypo-coagulable phenotype, compared to traditional
O, Espitia, M, Fouassier
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Thrombin Generation Assays (TGAs)
2017In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based
SALVAGNO, GIAN LUCA, Berntorp, Erik
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Thrombin generation in rheumatoid arthritis
Joint Bone Spine, 2012Joint Bone Spine - In Press.Proof corrected by the author Available online since samedi 2 juin ...
Clément, Prati +4 more
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Titania Gel Reduces Thrombin Generation
Artificial Organs, 2002Abstract: Titanium alloy (Ti) commonly is used for long‐term blood pumps as a conventional blood contacting material. Thrombus formation in the pump, however, is still a critical problem. Once thrombin is generated on the Ti surface, it activates platelets and the coagulation cascade, leading to thrombus formation.
Hiroshi, Ishitoya +8 more
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Thrombin generation by hemolysis
Blood Coagulation & Fibrinolysis, 2007Hemolysis is the fragmentation of erythrocytes into microparticles (Hb-MP). Clinical hemolysis can result in a severe procoagulant state. The influence of Hb-MP on thrombin generation was quantified. Unfrozen citrated normal plasma (five donors) was supplemented with 0 or 1 g/l Hb-MP obtained through erythrocyte destruction by hypotonic lysis, freezing/
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Thrombin generation in severe sepsis
Thrombosis Research, 2012Hemostasis and inflammation are two tightly interrelated systems in the host's response to infection. Thrombin generation in sepsis plays a crucial role in enhancing and modulation of inflammation. The present study aimed to investigate the course of thrombin generation in patients with severe sepsis, and its correlation with outcome.Thrombin ...
S, Petros +3 more
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Control Mechanisms in Thrombin Generation
Seminars in Thrombosis and Hemostasis, 1996Thrombin accelerates its own production by activating platelets (and perhaps other cells) to provide coagulant surfaces on which prothrombinase, the enzyme complex that activates prothrombin in plasma and consists of equimolar factor Xa (serine protease) and factor Va (cofactor), assembles in a Ca(2+)-dependent reaction.
F A, Ofosu, L, Liu, J, Freedman
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