Results 11 to 20 of about 20,052 (177)

Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population‐Based Study on Treatment Patterns, Vascular Complications and Survival [PDF]

European Journal of Haematology, Volume 116, Issue 5, Page 545-557, May 2026.
ABSTRACT Background Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well‐recognized increased risk of thrombotic events, bleeding, and all‐cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.
Anneli Enblom Larsson, Henrik Renlund, Björn Andréasson, Henrik Holmberg, Maria Liljeholm, Anders Själander   +5 more
wiley   +2 more sources

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms [PDF]

, 2015
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,
Aranaz, P., Aranaz, P., Bandinelli, S., Bandinelli, S., Barosi, G., Barosi, G., Baxter, E.J., Baxter, E.J., Callaway, A., Callaway, A., Campbell P., Campbell P., Cazzola, M., Cazzola, M., Chase, A., Chase, A., Chen, E., Chen, E., Cross N.C., Cross N.C., Dohner, K., Dohner, K., Duncombe, A.S., Duncombe, A.S., Evans, P., Evans, P., Ewing, J., Ewing, J., Gale, R.E., Gale, R.E., Giannopoulos, A., Giannopoulos, A., Gisslinger, H., Gisslinger, H., Godfrey, A.L., Godfrey, A.L., Grallert, H., Grallert, H., Green, A.R., Green, A.R., Griffiths, M., Griffiths, M., Guglielmelli, P., Guglielmelli, P., Haferlach, T., Haferlach, T., Harrison, C., Harrison, C., Harutyunyan, A.S., Harutyunyan, A.S., Jack, A., Jack, A., Jones, A.V., Jones, A.V., Kralovics, R., Kralovics, R., Leung, W., Leung, W., Lin, F., Lin, F., Maclean, C., Maclean, C., Mannarelli, C., Mannarelli, C., Mead, A.J., Mead, A.J., Nangalia, J., Nangalia, J., Oscier, D., Oscier, D., Pieri, L., Pieri, L., Reiter, A., Reiter, A., Schnittger, S., Schnittger, S., Schuh, A., Schuh, A., Short, M., Short, M., Stegelmann, F., Stegelmann, F., Strauch, K., Strauch, K., Tanaka, T., Tanaka, T., Tapper, W., Tapper, W., Vannucchi, A., Vannucchi, A., Waghorn, K., Waghorn, K., Wallis, L., Wallis, L., Ward, D., Ward, D., White, H.E., White, H.E., Zoi, K., Zoi, K.   +99 more
core   +5 more sources

Splanchnic vein thrombosis in myeloproliferative neoplasms: Pathophysiology and molecular mechanisms of disease [PDF]

, 2016
Myeloproliferative neoplasms (MPNs) are the most common underlying prothrombotic disorder found in patients with splanchnic vein thrombosis (SVT). Clinical risk factors for MPN-associated SVTs include younger age, female sex, concomitant hypercoagulable ...
How, Joan, Oh, Stephen T, Zhou, Amy
core   +2 more sources

Budd-Chiari syndrome recurring in a transplanted liver [PDF]

, 1983
A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent ...
Andrew Dekker, Asbury, Bras, Calne, Dane R. Boggs, David H. Van Thiel, Howard J. Seltman, Mitchel, Parker, Putnam, Takeuchi, Thomas E. Starzl   +11 more
core   +1 more source

Essential Thrombocythemia in a Cat

Journal of Veterinary Internal Medicine, 1990
Abstarct The diagnosis of essential thrombocythemia in a cat was made by fulfilling the five applicable criteria set forth by the Polycythemia Vera Study Group forusein humans. The criteria were 1) a platelet count persistently above 600,000/μL, 2) a normal initial hematocrit that did not rise in response to iron therapy, 3) normal ...
A S, Hammer, C G, Couto, D, Getzy, M Q, Bailey   +3 more
openaire   +2 more sources

Role of blood cells dynamism on hemostatic complications in low-risk patients with essential thrombocythemia [PDF]

, 2015
Patients with essential thrombocythemia (ET) aged less than 60 years, who have not suffered a previous vascular event (low-risk patients), may develop thrombotic or hemorrhagic events.
Bassan, Renato, Bertozzi, Irene, Bl\uf6chl, Elisabeth Maria, Cortelazzo, Sergio, Corvetta, Daisy, De Biasi, Ercole, Elli, Elena, Gastl, G\ufcnther, Gherlinzoni, Filippo, Gottardi, Michele, Guella, Anna, Innella, Barbara, Krampera, Mauro, Marabese, Alessandra, Marcheselli, Luigi, Mitterer, Manfred, Pacquola, Enrica, Perbellini, Omar, Piccin, Andrea, Pizzolo, Giovanni, Pogliani, Enrico Maria, Pusceddu, Irene, Randi, Maria Luigia, Rocconi, Roberta, Sancetta, Rosaria, Steurer, Michael, Tiribelli, Mario, Veneri, Dino, Vivaldi, Paolo   +28 more
core   +1 more source

Abnormal regulation of soluble and anchored IL-6 receptor in monocytes from patients with essential thrombocythemia [PDF]

, 2010
Objective: In a previous study, we found increased plasma soluble receptor for interleukin-6 (sIL-6R) levels in patients with essential thrombocythemia (ET) that could promote megakaryopoiesis through IL-6 binding and further interaction with the signal ...
Alvarez-Larrán, Ana C. Glembotsky, Arellano-Rodrigo, Barillé, Bauer, Baxter, Briso, Carlos D. Chazarreta, Chomczynski, Coles, Felisa C. Molinas, Gallea-Robache, Horiuchi, Jones, Jones, Jones, Jones, Jones, Juan P. Salim, Kralovics, Labbaye, Levine, Levine, Marta, Marta, Matthews, Mitsuyama, Mudter, Mullberg, Murakami-Mori, Murphy, Müllberg, Nakanishi, Nakashima, Nora P. Goette, Pang, Paola R. Lev, Pardanani, Park, Paula G. Heller, Rameshwar, Rosana F. Marta, Rose-John, Sui, Trikha, Varghese, Waetzig, Zheng   +47 more
core   +1 more source

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia [PDF]

, 2011
BACKGROUND: The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVE: The aim of this study was to detect the following mutations: JAK2 V617F, JAK2 exon
Cerutti, Janete Maria, Chauffaille, Maria de Lourdes Lopes Ferrari, Ribeiro, Juliana Corrêa da Costa, Santos, Leonardo Caires dos, Silva, Maria Regina Regis da, Silva, Neusa Pereira da   +5 more
core   +3 more sources

Calreticulin Type 26 Mutation in Myelofibrosis: A Rare Variant With Diagnostic Challenges

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background Myeloproliferative neoplasms (MPNs) are clonal hematologic disorders commonly driven by mutations in JAK2, MPL, or CALR. Because routine CALR assays are largely optimized for the canonical Type 1 and Type 2 exon 9 variants, rare noncanonical mutations may be missed, creating diagnostic challenges.
Teresa Maltese, Giuseppina Raffa, Fabio Stagno, Rossana Leanza, Paola Barone, Alessandro Allegra, Teresa Pollicino   +6 more
wiley   +1 more source

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. [PDF]

, 2018
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Aungier, Juliet, Bennett, Cavan, Dovey, Oliver M, Ghevaert, Cedric, Gonzalez-Arias, Carlos, Green, Anthony R, Grinfeld, Jacob, Hamilton, Tina L, Kent, David G, Klampfl, Thorsten, Li, Juan, Loughran, Stephen, Park, Hyun Jung, Pask, Dean C, Prins, Daniel, Sneade, Rachel, Vassiliou, George S, Williams, Matthew   +17 more
core   +1 more source