Results 31 to 40 of about 20,052 (177)

CDK6 inactivation counteracts CALR‐mutant‐induced MPN evolution and sensitizes MPN stem cells to interferon‐α treatment

open access: yesHemaSphere, Volume 10, Issue 5, May 2026.
Abstract Interferon‐α (IFNα) remains a potent therapeutic option for myeloproliferative neoplasms (MPNs) with an activated JAK/STAT signaling axis. However, variable patient responses highlight the need for optimized combination strategies. Recent studies suggest a link between cyclin‐dependent kinase 6 (CDK6) and IFN signaling.
Brian Ringhofer   +18 more
wiley   +1 more source

Biomolecular and histological features in pediatric essential thrombocythemia: adequacy of who diagnostic criteria [PDF]

open access: yes, 2017
Myeloproliferative neoplasms (MPN), Essential Thrombocythemia (ET), Polycythemia Vera (PV) and primary myelofibrosis (PMF), are clonal disorders of the hematopoietic stem cell.
Bertozzi, Irene
core   +1 more source

Myeloproliferative neoplasms: a review of diagnostic criteria and clinical aspects [PDF]

open access: yes, 2010
Chronic myeloproliferative disorders, currently called myeloproliferative neoplasms (MPN), according to the 4th edition of the World Health Organization (WHO) classification are clonal diseases of hematopoietic stem cells, in which there is increased ...
Chauffaille, Maria de Lourdes Lopes Ferrari
core   +1 more source

Thrombosis in Low‐Risk Polycythemia Vera: Insights From a Large Real‐World Cohort

open access: yesHematological Oncology, Volume 44, Issue 3, May 2026.
ABSTRACT Polycythemia vera (PV) is a myeloproliferative neoplasm driven by JAK2 mutations and associated with thrombotic complications. Current risk stratification classifies younger patients without prior thrombosis as low‐risk (LR), yet long‐term outcomes in this group remain poorly defined.
Inbar Cohen   +3 more
wiley   +1 more source

Pathophysiological aspects of Platelet-Mediated Thrombosis and Bleeding in Essential Thrombocythemia: [PDF]

open access: yes, 1998
Thrombocytosis, i.e. an elevation of the platelet count, is a common finding in clinical practice. In general, patients with thrombocytosis are distinguished into two main categories, primarily based on the cause underlying the increased platelet count ...
Genderen, P.J.J. (Perry) van
core   +1 more source

Measurement of spleen volume by ultrasound scanning in patients with thrombocytosis: a prospective study. [PDF]

open access: yes, 2002
Spleen size was assessed in 73 patients with thrombocytosis and in 15 healthy subjects, comparing palpation with ultra-sonography (US) measurement of longitudinal diameter and volume.
A. SODANO   +7 more
core   +1 more source

Thrombotic and hemorrhagic complications in idiopathic erythrocytosis [PDF]

open access: yes, 2017
We report clinical features of a large cohort of patients with IE compared to a cohort of patients with PV, focusing on the thrombotic and hemorrhagic ...
Bertozzi, Irene   +5 more
core   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

open access: yes
Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson   +5 more
wiley   +1 more source

Liver Transplantation Outcomes in Crigler‐Najjar Syndrome in Iran: A Single‐Center Retrospective Cohort Study Over 20 Years

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Crigler‐Najjar Syndrome (CNS) is a rare autosomal recessive disorder caused by uridine diphosphate glucuronosyltransferase (UGT1A1) deficiency, leading to unconjugated hyperbilirubinemia. Without treatment, patients are at high risk of kernicterus and irreversible neurological damage.
Sajad Teimoury   +6 more
wiley   +1 more source

This Is Not a Myeloproliferative Neoplasm…

open access: yes
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Stephanie Juané Kennedy
wiley   +1 more source

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