Results 31 to 40 of about 15,175 (215)

Genetic studies of hereditary thrombocythemia [PDF]

, 2013
Hereditary thrombocythemia (HT) is a familial myeloproliferative disorder characterized by an elevated platelet count in peripheral blood. Thrombocytosis is due to a genetic alteration that can be transmitted to the offspring.
Pianta, Annalisa
core   +1 more source

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat. [PDF]

, 2020
In a phase-2 study, the telomerase inhibitor imetelstat induced rapid hematologic responses in all patients with essential thrombocythemia who were refractory or intolerant to prior therapies.
Snyder, David S., Olatoyosi Odenike, Gabriela M. Baerlocher, Gary Spitzer, David S. Snyder, Oliver G. Ottmann, McDevitt, Michael A, Michael A. McDevitt, Röth, Alexander, Alexander Röth, Ottmann, Oliver G., Spitzer, Gary, Monika Haubitz, Bart Burington, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Ottmann, Oliver G, Baerlocher, Gabriela M., Haubitz, Monika, Snyder, David S, Burington, Bart, Elisabeth Oppliger Leibundgut, McDevitt, Michael A.   +22 more
core   +1 more source

Pregnancy with Essential Thrombocythemia: A Case Report

Taiwanese Journal of Obstetrics & Gynecology, 2004
Objective: We describe a woman with essential thrombocythemia (ET) who experienced a successful pregnancy with no specific treatment. Case Report: A 30-year-old primiparous female was incidentally found to have ET with no specific symptoms at a ...
Yin-Jou Chou, Yu-Che Ou, Shiuh-Young Chang, Te-Yao Hsu   +3 more
doaj   +1 more source

Isolated ten-eleven translocation 2 positive in triple negative essential thrombocythemia: Case report and literature review

SAGE Open Medical Case Reports, 2021
Essential thrombocythemia is one of the famous diseases under the category of myeloproliferative disorder. It is an end result of a genetic mutation of one or more of the most frequent oncogenes such as Janos kinase 2 (JAK2), MPL proto-oncogene ...
Rehab Y AL-Ansari, Dena Al Otaibi, Nourah Al Hudaithi, Leena Abdalla   +3 more
doaj   +1 more source

Studies of JAK2 mutations in myeloproliferative disorders [PDF]

, 2008
Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
core   +1 more source

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia. [PDF]

, 2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients
Snyder, David S., McDevitt, Michael A, Röth, Alexander, Ottmann, Oliver G., Spitzer, Gary, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Stuart, Monic, Ottmann, Oliver G, Baerlocher, Gabriela M., Daskalakis, Michael, Snyder, David S, Burington, Bart, McDevitt, Michael A.   +13 more
core   +1 more source

Recurrent thrombosis of splanchnic and lower extremity arteries with essential thrombocythemia

SAGE Open Medical Case Reports, 2019
Essential thrombocythemia is a myeloproliferative neoplasm characterized by platelet aggregation and thrombosis. Clinically, essential thrombocythemia increases the risk of both thrombosis and bleeding. Essential thrombocythemia is more involved in micro-
Sung Min Jung, Heungman Jun
doaj   +1 more source

Late‐Onset Chorea in JAK2‐Associated Essential Thrombocythemia [PDF]

, 2021
Somatic mutations in JAK2 are associated with chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF).
Mulroy, E, Di Lazzaro, G, Giulia Di Lazzaro, Koya Kutty, Shahedah, Shahedah, KK, Di Lazzaro, Giulia, Magrinelli, F, Mulroy, Eoin, Latorre, A, Anna Latorre, Shahedah Koya Kutty, Francesca Magrinelli, Bhatia, KP, Latorre, Anna, Eoin Mulroy, Bhatia, Kailash P, Kailash P. Bhatia, Magrinelli, Francesca   +17 more
core   +1 more source

Risk of Transformation to Acute Myeloid Leukaemia and Myelodysplastic Syndromes in Patients With Myeloproliferative Neoplasms Over Attained Age and Time Since Diagnosis: A Nationwide Cohort Study. [PDF]

Eur J Haematol
ABSTRACT Background Individuals with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) face transformation risks to acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). While older age is linked to increased risk, it remains unclear whether risk increases with age or with disease duration.
Batyrbekova N, Landtblom AR, Hultcrantz M, Szulkin R, Dickman PW, Andersson TM.   +5 more
europepmc   +2 more sources

Essential Thrombocythemia

JAMA
ImportanceEssential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.ObservationsPatients with essential thrombocythemia have a persistent platelet count of 450 
Ayalew, Tefferi, Naseema, Gangat, Giuseppe Gaetano, Loscocco, Paola, Guglielmelli, Natasha, Szuber, Animesh, Pardanani, Attilio, Orazi, Tiziano, Barbui, Alessandro Maria, Vannucchi   +8 more
  +7 more sources