Results 51 to 60 of about 15,175 (215)

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia

Haematologica, 2013
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear.
Anna L. Godfrey, Edwin Chen, Francesca Pagano, Yvonne Silber, Peter J. Campbell, Anthony R. Green   +5 more
doaj   +1 more source

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, EarlyView.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

JAK2 V617F Mutation in Adult Taiwanese Patients with Essential Thrombocythemia: More Prevalent in Old Patients and Correlated with Higher Hemoglobin Level and Higher Leukocyte Count

, 2017
Background: Essential thrombocythemia (ET) is classified as a chronic myeloproliferative neoplasm. JAK2 V617F mutation is found in about 50-60% patients with ET. We aim to determine the prevalence of JAK2 V617F mutation and its association with phenotype
Lin, Huan-Chau;Chen, Caleb Gon-Shen;Chang, Ming-Chih;Wang, Wei-Ting;Kao, Chen Wei;Lo, An-Chi;Su, Nai-Wen;Chang, Yu-Cheng;Chiang, Yi-Hao;Chou, Kuei-Fang;Liao, Po-Nien;Cai, Guan-Jhe;Cheng, Hung-I;Lin, Johnson;Chang, Yi-Fang;Hsieh, Ruey-Kuen;Lim, Ken-Hong
core   +1 more source

Neurological disorders in essential thrombocythemia

Haematologica, 2011
Patients with essential thrombocythemia often complain of various subjective neurological symptoms. This prospective study aims to assess their incidence and response to therapy.
Segolene Billot, Eirini G. Kouroupi, Johan Le Guilloux, Bruno Cassinat, Caroline Jardin, Thierry Laperche, Pierre Fenaux, Antoine F. Carpentier, Jean-Jacques Kiladjian   +8 more
doaj   +1 more source

Neurovascular Disorders in Pregnancy: Prevalence, Clinical Assessment and Management—A Review of the Literature

The Obstetrician &Gynaecologist, EarlyView.
ABSTRACT Key Content Neurovascular conditions in pregnancy are rare but are associated with poor maternal and fetal outcomes. This review covers the prevalence, clinical presentation, diagnosis and management of neurovascular disorders in pregnancy. The approach to clinical assessment and investigation of pregnant women with acute or changing chronic ...
Amy Newnham, Joshua Odendaal, Toby Keown, Wen‐Xern Chong, Krunal Patel, Vandana Dhingra   +5 more
wiley   +1 more source

Modern Approaches to Diagnosis and Treatment of Essential Thrombocythemia: Literature Review and Own Experience

Клиническая онкогематология, 2015
Objective. The aim of our study was to present literature data and own experience about epidemiology, terminology, etiology and pathogenesis of еssential thrombocythemia. Methods.
K. M. Abdulkadyrov, Vasilii Anatol’evich Shuvaev, I. S. Martynkevich   +2 more
doaj   +1 more source

Essential Thrombocythemia in a Dog

Journal of Veterinary Medical Science, 2006
A two-year old male Welsh Corgi was referred for persistent thrombocytosis and occasional seizure. Hematological findings indicated marked thrombocytosis, eosinophilia, basophilia and moderate anemia. Bone marrow examination revealed marked megakaryocytic hyperplasia with morphologic abnormality.
MIZUKOSHI, Takeshi, FUJINO, Yasuhito, YASUKAWA, Kuniyoshi, MATUMOTO, Hidefumi, MATSUMURA, Shingo, NAGASAKI, Teppei, OHNO, Koichi, TSUJIMOTO, Hajime, SHIMODA, Tetsuya   +8 more
openaire   +3 more sources

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, Volume 10, Issue 4, Page 1356-1364, July 2026.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Hidden in Plain Sight: Systemic Mastocytosis Manifesting as Isolated Hepatosplenomegaly in the Absence of Cutaneous and Classical Manifestations—A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Systemic mastocytosis (SM) is a rare clonal myeloproliferative neoplasm typically characterized by cutaneous lesions and mediator‐release symptoms. Presentations dominated by visceral organ involvement without skin findings are uncommon and pose a significant diagnostic challenge, often mimicking hematologic malignancies.
Muhammad Sadam Zeb, Ubaid Ullah Mian, Kashif Khan, Aiman Gulalay, Alishba Hameed, Alyan Malook, Essam Saeed, Suleman Khan, Muhammad Mujtaba, Kamil Ahmad Kamil   +9 more
wiley   +1 more source