Results 41 to 50 of about 20,052 (177)

Development of a highly sensitive method for detection of JAK2V617F [PDF]

, 2011
Background Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage.
Anna H Zhao, Rufei Gao, Zhizhuang J Zhao
core   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, Volume 101, Issue 4, Page 697-709, April 2026.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

Association Between Transfusion Status, Hemoglobin Levels, and Patient‐Reported Outcomes in Myelofibrosis: A Post Hoc Clinical Trial Analysis

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Quality of life and symptom burden of patients with myelofibrosis are well recognized and compounded in those with anemia; however, the effects of transfusion burden or anemia severity on quality of life have not been comprehensively characterized.
Ruben Mesa, Jeanne M. Palmer, Francesca Palandri, Lucia Masarova, Claire N. Harrison, Flora Mazerolle, Manal M'hari, Tom Liu, Shiyuan Zhang, Anna Cardellino, Zhaohui Wang, Catherine E. Ellis, Dwaipayan Patnaik, Antoine Regnault, Thomas W. LeBlanc   +14 more
wiley   +1 more source

Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count [PDF]

, 1994
We present a 4-year follow-up of a 42-year-old patient with primary thrombocythemia whose clinical course was complicated by two major mucocutaneous bleeding episodes.
Genderen, P.J.J. (Perry) van, Michiels, J.J. (Jan), Poel-van de Luytgaarde, S.C. (Sonja) van der, Vliet, H.H.D.M. (Huib) van   +3 more
core   +1 more source

Stent Thrombosis: A Narrative Review From Pathophysiology to Therapy

Clinical Cardiology, Volume 49, Issue 4, April 2026.
Stent thrombosis remains a life‐threatening complication of PCI driven by complex interactions between stent design, procedural factors, thrombogenic milieu, and inflammation. This review integrates pathophysiological mechanisms with contemporary and emerging therapeutic strategies, highlighting optimized PCI, tailored antithrombotic therapy, and novel
Emanuele Cecchi, Andrea Grasso Granchietti, Ruggero Mazzotta, Manuel Garofalo, Giorgia Panichella, Giuseppe Iula, Francesca Maria Di Muro, Silvia Menale, Rossella Marcucci   +8 more
wiley   +1 more source

Erdheim‐Chester disease associated with myeloid neoplasm: Clinical features, molecular landscape, and treatment outcomes

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Erdheim‐Chester disease (ECD) is frequently associated with clonal hematopoiesis and myeloid neoplasms (MN), but clinical phenotype and response to kinase inhibitors (KI) in this setting remain unclear. We analyzed 67 patients with ECD associated with MN (ECD‐MN) from a French national cohort and assessed ECD treatment response, MN progression,
Ambroise Le Pogam, Matthias Papo, Pierre Hirsch, Fleur Cohen‐Aubart, Jean‐François Emile, François Delhommeau, Pierre Duffau, Jérôme Razanamahery, Florence Nguyen‐Khac, Christopher Nunes Gomes, Felicien Triboulet, Jeanne de La Rochefoucauld, Chloé McAvoy, Estibaliz Lazaro, Mehdi Hage‐Sleiman, Damien Roos‐Weil, François Chasset, Vincent Jachiet, Arsène Mekinian, Olivier Fain, Zahir Amoura, Jérôme Hadjadj, Julien Haroche   +22 more
wiley   +1 more source

Role of Chitinase 3–like‐1 in Myelofibrosis via Fibroblast‐Produced Extracellular Matrix Enhancement

Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.
Our results indicate the involvement of CHI3L1 in the fibrocyte–fibroblast interaction and exacerbate BM fibrosis by promoting extracellular matrix formation. CHI3L1 is a missing link between fibrocytes and myofibroblasts and is a new potential therapeutic target for MF treatment.
Shoichiro Kato, Toshikuni Kawamura, Takaaki Maekawa, Hiraku Ogata, Noriaki Tachi, Yukiko Osawa, Shinichi Kobayashi   +6 more
wiley   +1 more source

Immunohistochemical characterization of the 'intimal proliferation' phenomenon in Sneddon's syndrome and essential thrombocythaemia [PDF]

, 1994
Cellular changes were immunocytochemically characterized in skin vessels of five patients with idiopathic generalized racemose livedo (Sneddon's syndrome), and one patient with localized racemose livedo associated with essential thrombocythaemia ...
Jungkunz, W., Marsch, W. C., Tamm, Ernst R., Wolter, M.   +3 more
core   +1 more source

Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital [PDF]

, 2016
We studied the implementation of JAK2 mutation analysis in conjunction with the World Health Organisation (WHO) guidelines in the pathway to MPN diagnosis in 279 patients presenting with one of three clinical scenarios: erythrocytosis, OR leukocytosis ...
Poulet, Erma
core  

One Grammar, Many Labels: Revisiting the Continuum of Myeloid Neoplasms

Hematological Oncology, Volume 44, Issue 3, May 2026.
Francesco Tarantini, Cosimo Cumbo, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Angela Minervini, Giuseppina Tota, Elisa Parciante, Immacolata Redavid, Maria Rosa Conserva, Crescenzio Francesco Minervini, Angelo Cellamare, Paola Casieri, Maria Cristina Nuzzi, Paola Caforio, Alessandra Ricco, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +18 more
wiley   +1 more source