Results 21 to 30 of about 2,897,878 (123)

Studies of JAK2 mutations in myeloproliferative disorders [PDF]

, 2008
Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
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Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia. [PDF]

, 2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients
Snyder, David S., McDevitt, Michael A, Röth, Alexander, Ottmann, Oliver G., Spitzer, Gary, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Stuart, Monic, Ottmann, Oliver G, Baerlocher, Gabriela M., Daskalakis, Michael, Snyder, David S, Burington, Bart, McDevitt, Michael A.   +13 more
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Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat. [PDF]

, 2020
In a phase-2 study, the telomerase inhibitor imetelstat induced rapid hematologic responses in all patients with essential thrombocythemia who were refractory or intolerant to prior therapies.
Snyder, David S., Olatoyosi Odenike, Gabriela M. Baerlocher, Gary Spitzer, David S. Snyder, Oliver G. Ottmann, McDevitt, Michael A, Michael A. McDevitt, Röth, Alexander, Alexander Röth, Ottmann, Oliver G., Spitzer, Gary, Monika Haubitz, Bart Burington, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Ottmann, Oliver G, Baerlocher, Gabriela M., Haubitz, Monika, Snyder, David S, Burington, Bart, Elisabeth Oppliger Leibundgut, McDevitt, Michael A.   +22 more
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Late‐Onset Chorea in JAK2‐Associated Essential Thrombocythemia [PDF]

, 2021
Somatic mutations in JAK2 are associated with chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF).
Mulroy, E, Di Lazzaro, G, Giulia Di Lazzaro, Koya Kutty, Shahedah, Shahedah, KK, Di Lazzaro, Giulia, Magrinelli, F, Mulroy, Eoin, Latorre, A, Anna Latorre, Shahedah Koya Kutty, Francesca Magrinelli, Bhatia, KP, Latorre, Anna, Eoin Mulroy, Bhatia, Kailash P, Kailash P. Bhatia, Magrinelli, Francesca   +17 more
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Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia

Background: We conducted a randomized comparison of hydroxyurea with anagrelide in the treatment of essential thrombocythemia. Methods: A total of 809 patients with essential thrombocythemia who were at high risk for vascular events received low-dose ...
Revell P, for the United Kingdom Medical Research Council Primary Thrombocythemia 1 Study, Reilly JT, Campbell PJ, Wilkins BS, Bareford D, Woodcock BE, Wheatley K, Grigg AP, East CL, Harrison CN, van der Walt JD, Green AR, Buck G   +13 more
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A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family

Haematologica, 2008
Background Hereditary thrombocythemia is an autosomal dominant disorder with clinical features resembling sporadic essential thrombocythemia.
Kun Liu, Robert Kralovics, Zbigniew Rudzki, Barbara Grabowska, Andreas S. Buser, Damla Olcaydu, Heinz Gisslinger, Ralph Tiedt, Patricia Frank, Krzysztof Okoñ, Anthonie P.C. van der Maas, Radek C. Skoda   +11 more
doaj   +1 more source

A Case of Symptomatic Intraluminal Internal Carotid Artery Thrombus in a Patient with Essential Thrombocythemia Surgically Treated by CEA

Case Reports in Neurological Medicine, 2023
We report a patient with a symptomatic intraluminal internal carotid artery thrombus clinically revealed by cerebral infarction. In the preoperative evaluation, it was revealed that essential thrombocythemia existed in the background.
Satoshi Takahashi, Masahiro Katsumata, Hirotsugu Nogawa, Kento Takahara, Jin Nakahara, Masahiro Toda   +5 more
doaj   +1 more source

The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity [PDF]

, 2010
The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling ...

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Familial Essential Thrombocythemia Associated with MPL W515L Mutation in Father and JAK2 V617F Mutation in Daughter

Case Reports in Hematology, 2014
Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report two patients—father and daughter—with essential thrombocythemia who displayed a heterogeneous ...
Adrian P. Trifa, Andrei Cucuianu, Radu A. Popp   +2 more
doaj   +1 more source

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established [PDF]

We previously reported the Marimo cell line, which was established from the bone marrow cells of a patient with essential thrombocythemia (ET) at the last stage after transformation to acute myeloid leukemia (AML).
Ishikawa, Yuichi, Ushijima, Yoko, Kawashima, Naomi, Sanada, Masashi, Nishiyama, Takahiro, Kanamori, Takashi, Kiyoi, Hitoshi   +6 more
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