Results 31 to 40 of about 21,457 (218)

THPO-MPL pathway and bone marrow failure

Hematology/Oncology and Stem Cell Therapy, 2015
Single or multilineage bone marrow failure can be a serious health problem caused by hereditary and non-hereditary causes such as exposure to drugs or environmental toxins.
Majed Dasouki, Irfan Saadi, Syed O Ahmed
doaj   +1 more source

Essential Thrombocythemia among Patients with Myeloproliferative Neoplasms in Haematology Unit of a Tertiary Care Centre: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2022
Introduction: Essential thrombocythemia, a myeloproliferative condition with an increased number of circulating platelets, is a rare hematological malignancy. The aim of the study is to find out the prevalence of essential thrombocythemia among patients
Sanjit Kumar Sah, Sangam Shah, Sansar Babu Tiwari, Basanta Sharma Poudel, Biranmol Singh, Prakash Sharma, Sunil Sharma Acharya, Hritik Murarka, Sabin Thapaliya, Anjan Shrestha   +9 more
doaj   +1 more source

Genetic studies of hereditary thrombocythemia [PDF]

, 2013
Hereditary thrombocythemia (HT) is a familial myeloproliferative disorder characterized by an elevated platelet count in peripheral blood. Thrombocytosis is due to a genetic alteration that can be transmitted to the offspring.
Pianta, Annalisa
core   +1 more source

Does Reactive Thrombocytosis Observed in Iron Deficiency Anemia Affect Plasma Viscosity?

Turkish Journal of Hematology, 2012
OBJECTIVE: The accompanying thrombocytosis is referred to as the major factor associated with thromboembolism in iron deficiency anemia (IDA). Increased viscosity may increase the risk of thrombosis.
Selami K. Toprak, İbrahim Tek, Sema Karakuş, Nihat Gök, Nazmiye Kurşun   +4 more
doaj   +1 more source

Studies of JAK2 mutations in myeloproliferative disorders [PDF]

, 2008
Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
core   +1 more source

Essential thrombocythemia [PDF]

, 1998
Review on Essential thrombocythemia, with data on clinics, and the genes ...
Huret, JL
core   +1 more source

Retinal neovascularization in the setting of -mutation positive essential thrombocythemia

SAGE Open Medical Case Reports, 2023
Patients with Calreticulin ( CALR ) mutation positive essential thrombocythemia are often thought of as having a “low-risk” of thrombotic complications.
Stanton P Heydinger, Marwan R Abdulaal, Angeline L Wang   +2 more
doaj   +1 more source

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat. [PDF]

, 2020
In a phase-2 study, the telomerase inhibitor imetelstat induced rapid hematologic responses in all patients with essential thrombocythemia who were refractory or intolerant to prior therapies.
Snyder, David S., Olatoyosi Odenike, Gabriela M. Baerlocher, Gary Spitzer, David S. Snyder, Oliver G. Ottmann, McDevitt, Michael A, Michael A. McDevitt, Röth, Alexander, Alexander Röth, Ottmann, Oliver G., Spitzer, Gary, Monika Haubitz, Bart Burington, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Ottmann, Oliver G, Baerlocher, Gabriela M., Haubitz, Monika, Snyder, David S, Burington, Bart, Elisabeth Oppliger Leibundgut, McDevitt, Michael A.   +22 more
core   +1 more source

Thromboembolic complication in Essential Thrombocythemia

The Pan African Medical Journal, 2012
The presenting symptoms of patients with essntial thrombocythemia are quite variable. After detection of thrombocytosis about 13 to 37 percent of patients relate symptoms due to hemorrhagic event, and about 22 to 84 percent of patients report ...
Zahra Mozaheb
doaj   +1 more source

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia. [PDF]

, 2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients
Snyder, David S., McDevitt, Michael A, Röth, Alexander, Ottmann, Oliver G., Spitzer, Gary, Oppliger Leibundgut, Elisabeth, Odenike, Olatoyosi, Stuart, Monic, Ottmann, Oliver G, Baerlocher, Gabriela M., Daskalakis, Michael, Snyder, David S, Burington, Bart, McDevitt, Michael A.   +13 more
core   +1 more source