Results 61 to 70 of about 32,411 (197)

Carotid Endarterectomy in the Acute Period of Ischemic Stroke After Thrombolytic Therapy

Неотложная медицинская помощь
AIM OF STUDY. To study the outcomes, complications and risk factors of CEA surgery in patients after thrombolytic therapy.MATERIAL AND METHODS. The results of treatment of patients after carotid endarterectomy in the acute period of ischemic acute ...
D. А. Nekrasov, D. Ya. Ziyarova, A. V. Gavrilenko   +2 more
doaj   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Multivalent Bi‐Specific Nanoerythrosomes: A Two‐Birds‐One‐Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis

Small, EarlyView.
A multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Yu Huang, Yilin Yang, Nicole Henry, Boram Gu, Jiahua Wang, Yuanyuan Guo, Colin Longstaff, Simon A. Thom, Yuehua Li, Xiao Yun Xu, Rongjun Chen   +10 more
wiley   +1 more source

The rationale for thrombolytic therapy [PDF]

European Heart Journal, 1996
Substantial progress has been made toward understanding the pathophysiological processes that lead to acute myocardial infarction. Research has shown that the mechanism of infarction is the rupture of an atherosclerotic plaque with a subsequent thrombogenic response from exposed subendothelial tissue, leading to additional or complete obstruction of ...
openaire   +2 more sources

Shear‐Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries

Small, EarlyView.
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E. Ingber, Zixiang Leonardo Liu, Netanel Korin   +10 more
wiley   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, EarlyView.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Postoperative Care and Management in Pediatric Hematology‐Oncology Patients

European Journal of Haematology, EarlyView.
ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley   +1 more source

Survey of status quo of knowledge,attitude and practice of community population on thrombolytic therapy of ischemic stroke patients in Beijing

Huli yanjiu, 2017
Objective:To analyze the status quo of knowledge,attitude and practice of community population on thrombolytic therapy of ischemic stroke patients in Beijing,so that community residents knew the importance of early treatment of ischemic stroke.Methods:A ...
曹闻亚, 杨莘, 常红, 乔雨晨, 王佳妹   +4 more
doaj  

Debate: Should the elderly receive thrombolytic therapy or primary angioplasty?

Current Controlled Trials in Cardiovascular Medicine, 2000
Thrombolysis and primary angioplasty are both recommended reperfusion strategies for elderly patients presenting with myocardial infarction (MI). Primary angioplasty is most beneficial in high-risk patients. While the elderly have a high absolute risk of
White Harvey D
doaj   +1 more source

Utility of the SWAM (Separator With Aspirator for Mechanical Thrombectomy) Device in Managing Hemodialysis Access Thrombosis

Hemodialysis International, EarlyView.
ABSTRACT Background Hemodialysis access thrombosis is the primary cause of access failure. Thrombus removal is an effective strategy to restore access function. Although both open surgical and endovascular procedures enable thrombus clearance, endovascular thrombus reduction therapy is widely adopted in clinical practice for this condition due to its ...
Lin Li, Zhongwang Zhang, Hongjie Wang, Mingdi Zhu, Kun Wang, Zheng Liu   +5 more
wiley   +1 more source