Results 71 to 80 of about 5,138,951 (296)
BMC NeurologyObjective To explore the safety of intravenous thrombolysis with alteplase (rt-PA) in the treatment of acute ischemic stroke (AIS) in the elderly (≥ 80 years old) and with analyze the influencing factors of its clinical outcome.
Yongyin Zhang +6 more
doaj +1 more source
Advanced Robotics Research, EarlyView.Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin +3 more
wiley +1 more source
A fibrin targeted molecular imaging evaluation of microvascular no‐reflow in acute ischemic stroke
Brain and Behavior, 2022 Objective To investigate the relationship between fibrin deposition and “no‐reflow” within microcirculation after thrombolysis in acute ischemic stroke (AIS).
Xi Chen +8 more
doaj +1 more source
rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome. [PDF]
, 2014 BackgroundBiologic sex can influence response to pharmacologic therapy. The purpose of this proof-of-concept study was to evaluate the medicating effects of estrogen in the efficacy of acute antiplatelet loading therapy on stroke outcome in the rabbit ...
Compton, M Peggy +4 more
core +3 more sources
Advances in Acute Ischemic Stroke Therapy.
Circulation Research, 2022 The treatment of acute ischemic stroke continues to advance. The mainstay of treatment remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later treatment with alteplase is beneficial in patients selected with advanced ...
Yunyun Xiong, A. Wakhloo, M. Fisher
semanticscholar +1 more source
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury
Advanced Science, EarlyView.Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu +11 more
wiley +1 more source
Southern Medical Journal, 1961 One of the most exciting areas in modern therapeutics relates to the development of clot-dissolving agents for the treatment of acute thromboembolic episodes. Such an objective seems entirely feasible, since fibrin, the major insoluble constituent of the clot, is susceptible to enzymatic lysis, and agents capable of effecting such enzymatic lysis may ...
openaire +4 more sources
Personification of the approaches to reperfusion therapy of ischemic stroke
Анналы клинической и экспериментальной неврологии, 2017 Introduction. Systemic thrombolytic therapy using recombinant tissue plasminogen activator (rtPA) is the gold standard of reperfusion therapy in certainpatients with ischemic stroke during the first 4.5 h after stroke onset. Objective.
Maksim A. Domashenko +5 more
doaj +1 more source
Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis
European Heart Journal, 2014 Aim Thrombolytic therapy induces faster clot dissolution than anticoagulation in patients with acute pulmonary embolism (PE) but is associated with an increased risk of haemorrhage.
C. Marti +7 more
semanticscholar +1 more source