Results 81 to 90 of about 2,550,374 (236)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

open access: yesPediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak   +5 more
wiley   +1 more source

Cost-utility analysis of thrombolytic therapy

open access: yes, 1991
An analysis of the cost-effectiveness of thrombolytic therapy was performed, based on 3- to 5-year follow-up data, from 533 patients randomized to receive conventional therapy or intracoronary streptokinase.
Vos, J. (Jeroen)   +2 more
core   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

open access: yesAnnals of Neurology, Volume 100, Issue 5, Page 964-978, November 2026.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary   +21 more
wiley   +1 more source

Thrombolytic therapy in pulmonary embolism. [PDF]

open access: yes, 2010
Massive pulmonary embolism carries a high mortality. Potential treatment includes anticoagulation, thrombolytic therapy and embolectomy. We report a case of deep vein thrombosis leading to progressive massive pulmonary embolism despite appropriate ...
Hayes, J, Nagi, D
core  

Update on Thrombolytic Therapy in Acute Pulmonary Thromboembolism

open access: yes, 2019
Thrombolytic treatment accelerates the dissolution of thrombus in acute pulmonary thromboembolism (PTE) and is potentially a lifesaving treatment. High-risk PTE is the clearest indication for this therapy, and its use in intermediate-risk cases is still ...
YILMAZEL UÇAR, Elif, Elif Yilmazel Ucar
core   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He   +4 more
wiley   +1 more source

Survey of status quo of knowledge,attitude and practice of community population on thrombolytic therapy of ischemic stroke patients in Beijing

open access: yesHuli yanjiu, 2017
Objective:To analyze the status quo of knowledge,attitude and practice of community population on thrombolytic therapy of ischemic stroke patients in Beijing,so that community residents knew the importance of early treatment of ischemic stroke.Methods:A ...
曹闻亚   +4 more
doaj  

Debate: Should the elderly receive thrombolytic therapy or primary angioplasty?

open access: yesCurrent Controlled Trials in Cardiovascular Medicine, 2000
Thrombolysis and primary angioplasty are both recommended reperfusion strategies for elderly patients presenting with myocardial infarction (MI). Primary angioplasty is most beneficial in high-risk patients. While the elderly have a high absolute risk of
White Harvey D
doaj   +1 more source

The origin of thrombolytic therapy

open access: yesJournal of the American College of Cardiology, 1989
The origin of thrombolytic therapy is briefly reviewed. It began 40 years ago with the demonstration that the injection into patients of a partially purified activator of the native plasminogen-plasmin enzyme system was capable of dissolving clotted blood and fibrinous loculations in the chest.
openaire   +2 more sources

Perspectives in Pediatric Ambulatory Anesthesia: Part 3—One Center's Evolving Regional Anesthesia Experience and Outcomes

open access: yesPediatric Anesthesia, Volume 36, Issue 11, Page 1341-1351, November 2026.
ABSTRACT Introduction Pediatric ambulatory surgery is the dominant model of surgical care in the U.S. and has impacted the practice of regional anesthesia (RA). Pediatric RA's use has expanded as a supplement to general anesthesia with the introduction of ultrasound.
David E. Liston   +5 more
wiley   +1 more source

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