Results 91 to 100 of about 16,590 (223)

Thrombomodulin and Lactate Dehydrogenase as Potential Predictors of Leg Ulcers in Sickle Cell Disease

International Journal of Medicine and Health Development
Background: Endothelial dysfunction, hypercoagulability, hemolysis, and vasculopathy are involved in the pathogenesis of sickle cell leg ulcers (SCLUs).
Helen C. Okoye, Sunday Ocheni, Lisa I. Eweputanna, Theresa U. Nwagha, Chioma S. Ejezie, Charles E. Nonyelu, Oji A. Nnachi, Onochie I. Obodo, Omolade A. Awodu   +8 more
doaj   +1 more source

Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia

, 2002
Because thrombomodulin plays a key role in the protein C pathway, we evaluated the contribution of thrombomodulin gene mutations to venous thrombosis.
F. Rodeghiero, G. Castaman, E. Faioni, E. Biguzzi, F. Franchi   +4 more
core   +1 more source

Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis

, 2011
Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Wan-Chung(Wan-Jiung) Hu, August Louis Bourgeois, Nathan Wolfe, Anne Jedlicka, Alan Scott, Sher Singh   +5 more
core  

Surface Re-engineering of Pancreatic Islets with Recombinant azido-Thrombomodulin

, 2016
Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker.
Wanxing Cui (323677), Xue-Long Sun (1432348), Carolyn A. Haller (2186491), Cherie L. Stabler (1894438), John T. Wilson (1954576), Elliot L. Chaikof (2140303)   +5 more
core   +1 more source

Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia

Respiratory Research
Background Vascular endothelial damage is involved in the development and exacerbation of ventilator-induced lung injury (VILI). Pulmonary endothelial glycocalyx and neutrophil extracellular traps (NETs) are endothelial protective and damaging factors ...
Kenichiro Kikuchi, Satoshi Kazuma, Michiaki Yamakage   +2 more
doaj   +1 more source

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

Paclitaxel Induces Thrombomodulin Downregulation in Human Aortic Endothelial Cells

, 2011
Patients with paclitaxel-eluting stents are at risk of developing stent thrombosis upon premature discontinuation of dual antiplatelet therapy. In this study, we set out to clarify whether paclitaxel can modulate thrombomodulin expression in human aortic
Wang, Huang-Joe, Lu, Te-Ling, Huang, Huey-Chun, Huang, Haimei   +3 more
core  

Incidence, Risk Factors, and Modified Risk Assessment Model of Venous Thromboembolism in Non‐Hodgkin Lymphoma Patients

Cancer Medicine
Background Venous thromboembolic events (VTEs) are the second‐leading cause of death in cancer patients, with an incidence of 5%–17% in lymphoma patients, particularly higher in those with non‐Hodgkin lymphoma (NHL). Existing risk assessment models (RAMs)
Wen Li, Rui Liu, Ying Shen, GongZhizi Gao, Rui Yang, Yiwen Wang, Ruoyu Yang, Zujie Lin, Ruijun Dong, Wanhong Zhao, Aili He, Ju Bai   +11 more
doaj   +1 more source

Plasma thrombomodulin levels in patients with Behcet's disease

, 2003
The plasma levels of thrombomodulin in 54 patients with Behcet's disease (BD) and 20 healthy control subjects were studied. The mean thrombomodulin (TM) level was significantly higher in active BD patients than in inactive patients and healthy controls ...
Ayaslioglu, E, Duzgun, N, Aydintug, O, Olmez, U, Sahin, M, Tutkak, H   +5 more
core   +1 more source

Saving placental thrombomodulin

Blood, 2021
Cha Han, Jing-fei Dong
openaire   +3 more sources