Results 71 to 80 of about 16,590 (223)

Loss of Placental Thrombomodulin in Oocyte Donation Pregnancies

, 2016
ObjectiveWomen pregnant after oocyte donation (OD) are prone to develop preeclampsia, a syndrome characterised by an aberrant immunologic response, hypercoagulability and endothelial dysfunction.
Baelde, H.J., Bloemenkamp, K.W.M., Bos, M., Bruijn, J.A., Turner, R.J., Hoorn, M.L.P. van der   +5 more
core   +1 more source

Reciprocal antagonism between inflammation and the protein C system

Romanian Journal of Laboratory Medicine, 2013
Proteina C, o protează serinică dependentă de vitamina K, sintetizată in hepatocite ca zimogen inactiv, se activează sub acţiunea trombinei în complex cu trombomodulina endotelială. Un receptor endotelial al proteinei C (EPCR) intervine atât în activarea
Cucuianu Mircea, Brudasca Ioana, Plesca Luminita, Bodizs Gyorgy, Colhon Dan, Cucuianu Andrei   +5 more
doaj   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals

Diabetes, Metabolic Syndrome and Obesity, 2020
Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Rabih Halwani,1,2 Salah Abusnana,2,3 Rifat Hamoudi,1,2 Nabil Sulaiman1,4,5 1Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates ...
Saheb Sharif-Askari F, Saheb Sharif-Askari N, Halwani R, Abusnana S, Hamoudi R, Sulaiman N   +5 more
doaj  

Whole exome sequencing identifies a mutation in thrombomodulin as the genetic cause of a suspected platelet disorder in a family with normal platelet function

Platelets, 2017
Here, we describe a mother and son with a lifelong bleeding tendency and posttraumatic bleeding who were recruited to the UK Genotyping and Phenotyping of Platelets (GAPP) study with a suspected platelet function disorder.
Annabel Maclachlan, Gerry Dolan, Charlotte Grimley, Steve P. Watson, Neil V. Morgan, on behalf of the UK GAPP Study Group   +5 more
doaj   +1 more source

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Research and Practice in Thrombosis and Haemostasis, 2020
Background The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3 randomized, double‐blinded, parallel‐group trial in Japan.
Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito   +7 more
doaj   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, Volume 7, Issue 3, June 2026.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

Gossypiboma‐associated sarcomas in five cases

Journal of Small Animal Practice, Volume 67, Issue 6, Page 520-527, June 2026.
Objectives To report clinical presentation, treatment and outcome of dogs and cats diagnosed with gossypiboma‐associated sarcoma. Materials and Methods Referral centres within the United Kingdom, Europe, North America and Australia were contacted to search medical records for dogs and cats with documented gossypiboma‐associated sarcoma and included if ...
G. Thomas, L. Doeven, A. Guillén, D. Brockman, E. Herbert, S. Priestnall, J. Helm, K. Shimura, M. Simpson   +8 more
wiley   +1 more source

Expression of thrombomodulin in patients with spontaneous occlusion of the circle of Willis.

, 1993
We examined the expression of thrombomodulin, a recently isolated anticoagulant protein, in endothelial cells from patients with spontaneous occlusion of the circle of Willis (cerebrovascular moyamoya disease) to determine whether lack of the expression ...
Y Hosoda, E Ikeda, I Maruyama
core   +1 more source

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha, Binita Shrestha, Takashi Ito, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama   +8 more
doaj   +1 more source