Results 71 to 80 of about 17,882 (212)

Evaluation of thrombomodulin (THBD) plasma levels in sickle cell disease and correlation with disease severity

open access: yesEgyptian Pediatric Association Gazette
Background Endothelial dysfunction is a hallmark of sickle vasculopathy. Thrombomodulin (THBD) is a transmembrane protein expressed on vascular endothelial cells suppressing blood coagulation and exerting anti-inflammatory effects.
Yasmeen M.M. Selim   +4 more
doaj   +1 more source

Association of thrombomodulin Ala455Val dimorphism and inflammatory cytokines with carotid atherosclerosis in the Chinese Han population

open access: yes, 2012
Gaochao Qian,1 Zhixiang Ding,1 Binxia Zhang,2 Qihua Li,2 Wentao Jin,1 Qi Zhang21Clinical Laboratory Department, 2Department of Cardiology, Changzhou TCM Hospital Affiliated to Nanjing TCM University, Changzhou, ChinaBackground and methods: It has been ...
Qian G   +5 more
core  

Paclitaxel Induces Thrombomodulin Downregulation in Human Aortic Endothelial Cells [PDF]

open access: yes, 2011
Patients with paclitaxel-eluting stents are at risk of developing stent thrombosis upon premature discontinuation of dual antiplatelet therapy. In this study, we set out to clarify whether paclitaxel can modulate thrombomodulin expression in human aortic
Wang, Huang-Joe   +3 more
core   +1 more source

T0901317 improves renal injury in db/db mice by activating liver X receptor α

open access: yesDi-san junyi daxue xuebao, 2020
Objective To determine the effects of liver X receptor (LXR) agonist T0901317 and thrombomodulin (TM) interfering RNA recombinant adenovirus Ad-TM shRNA on renal injury of db/db mice with diabetic nephropathy (DN).
WU Song, DU Yaqin, ZHANG Ping
doaj   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

open access: yesReviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria   +5 more
wiley   +1 more source

Light-for-Date児とAppropriate-for-Date児における臍帯血の血漿トロンボモジュリン値

open access: yes, 2018
Thrombomodulin, a thrombin receptor on the surface of endothelial cells, plays an important role not only in maintaining normal hemostatic balance but also in in utero development.
舩越, 康智
core  

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2020
Background The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3 randomized, double‐blinded, parallel‐group trial in Japan.
Takashi Ito   +7 more
doaj   +1 more source

Recombinant Human Soluble Thrombomodulin Suppresses Monocyte Adhesion by Reducing Lipopolysaccharide-Induced Endothelial Cellular Stiffening

open access: yesCells, 2020
Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation.
Takayuki Okamoto   +8 more
doaj   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

open access: yesReviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani   +2 more
wiley   +1 more source

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

open access: yesXenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters   +6 more
wiley   +1 more source

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