Results 81 to 90 of about 17,882 (212)
A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation [PDF]
, 2020 Thrombomodulin functions as an anticoagulant through thrombin binding and protein C activation. We herein report the first case of hereditary functional thrombomodulin deficiency presenting with recurrent subcutaneous hemorrhage and old cerebral ...
Tominaga, Norio +7 more
core +1 more source
Nature Communications, 2019 The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via ...
C. Peghaire +13 more
doaj +1 more source
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha +8 more
doaj +1 more source
Oxidation of Thrombomodulin Methionine 388 in Cigarette Smokers [PDF]
, 2013 This work tested the hypothesis that oxidation of methionine 388 in thrombomodulin is higher in cigarette smokers, and thus a likely contributor towards the hypercoagulable state in smokers.
Thapa, Samrat B.
core +3 more sources
Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis [PDF]
, 2011 Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Wan-Chung(Wan-Jiung) Hu +5 more
core
Trauma-Induced Coagulopathy: A Review of Specific Molecular Mechanisms
DiagnosticsTrauma remains a leading cause of death and disability in adults, and about 20% of deaths occur due to intractable bleeding. Trauma-induced coagulopathy (TIC) is a complex hemostatic disorder characterized by an abnormal coagulation response, which can ...
Andrea Capponi, Carlo Rostagno
doaj +1 more source
, 2009 Objective: To evaluate the association between maternal plasma thrombomodulin levels and infant birth weights in pregnancy-induced hypertension. Study design: Plasma thrombomodulin levels were measured in 80 pregnat women living in the Trakya region of ...
Varol, Fuesun G. +3 more
core +1 more source
Thrombin and the Coag-Inflammatory Nexus in Neurotrauma, ALS, and Other Neurodegenerative Disorders
Frontiers in Neurology, 2019 This review details our current understanding of thrombin signaling in neurodegeneration, with a focus on amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease) as well as future directions to be pursued.
Barry W. Festoff +3 more
doaj +1 more source
Expression of thrombomodulin in patients with spontaneous occlusion of the circle of Willis.
, 1993 We examined the expression of thrombomodulin, a recently isolated anticoagulant protein, in endothelial cells from patients with spontaneous occlusion of the circle of Willis (cerebrovascular moyamoya disease) to determine whether lack of the expression ...
Y Hosoda, E Ikeda, I Maruyama
core +1 more source
Guoji laonian yixue zazhi[Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR)
Chen Jing +3 more
doaj +1 more source