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Thrombophilic thrombomodulin variants
BloodIn this issue of Blood, Van Laer et al have expressed and extensively characterized 8 thrombomodulin (TM) variants of uncertain significance identified in patients with venous thromboembolism (VTE) or bleeding, demonstrating defective anticoagulant activity in 2 of them (L433P and C175S).1 Their findings, reported in this issue of Blood, support a ...
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Thrombomodulin Structure and Function
Thrombosis and Haemostasis, 1997Thrombomodulin is protein cofactor expressed on endothelial cell surfaces that modifies the substrate specificity of thrombin, apparently by an allosteric mechanism. The thrombin-thrombomodulin complex activates protein C, initiating an essential anticoagulant pathway.
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Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells
Proceedings of the National Academy of Sciences of the United States of America, 2021Hemant Giri +2 more
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The thrombomodulin–protein C system is essential for the maintenance of pregnancy
Nature Medicine, 2003Berend Isermann, Rashmi Sood
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