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Infants less than 6 months of age have decreased thromboplastin generation, resulting in part from a deficiency of plasma thromboplastin component. Some factor or factors other than a low level of plasma thromboplastin component may contribute to this deficiency.
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The Prothrombin Time (PT) test is used for monitoring of treatment with Vitamin K-antagonists (VKA). The result of the PT test should be expressed as the International Normalized Ratio (INR). Calculation of INR is based on the availability of International Standards (IS) for thromboplastin and a calibration model. Calibration of a new PT test system is
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Calibration of thromboplastins
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1995Anticoagulant therapy with coumarin drugs requires tests on the patient's blood to determine the dose rate for the drug. The tests involve measuring the effect of a preparation of a certain reagent, thromboplastin, in accelerating the clotting of the patient's blood.
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