Results 91 to 100 of about 72,706 (285)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding   +4 more
wiley   +1 more source

Heparin-induced prolongation of partial thromboplastin time after thrombolysis: Relation to coronary artery patency [PDF]

open access: yes, 1992
Having previously shown in the Heparin Aspirin Reperfusion Trial that the empiric use of early intravenous heparin after recombinant tissue-type plasminogen activator (rt-PA) is an important component in the overall treatment strategy, we examine in this
Chaitman, Bernard R.   +5 more
core   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad   +8 more
wiley   +1 more source

Changes in fibrinogen level after infusion of thrombin and thromboplastin

open access: yes, 1960
Dogs, rabbits and rats were infused with dilute solutions of thrombin or thromboplastin. Changes in fibrinogen levels were estimated by two methods. One method measured precipitable fibrinogen and the other measured changes in coagulability.
Susan Milojevic, Frank C. Monkhouse
core   +1 more source

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako   +11 more
wiley   +1 more source

Hematological Changes Post-Hemo and Peritoneal Dialysis Among Renal Failure Patients in Sudan

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2008
The objective of the study was to assess the changes that occur in various hematological parameters that may occur in renal failure patients after hemo and peritoneal dialysis sessions.
Mohamed Ali Mohamed   +4 more
doaj  

Prognostic value of the activated partial thromboplastin time after orthotopic liver transplantation. A prospective study

open access: yes, 1994
In this prospective study, we evaluated the predictive value of activated partial thromboplastin time on day 8 post transplantation for event-free survival in patients who had had orthotopic liver transplants; both death and retransplantation within 6 ...
B. Gridelli   +5 more
core   +1 more source

PENGARUH PENDIAMAN DARAH SITRAT PADA SUHU 2-8°C TERHADAP NILAI ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) [PDF]

open access: yes, 2022
Latar Belakang: Pemeriksaan APTT (Activated Partial Thromboplastin Time) adalah pemeriksaan rutin hemostasis yang digunakan untuk mengevaluasi mekanisme pembekuan darah pasien pada jalur instrinsik dan jalur bersama.
Afifah, Destine
core  

Seventh Åland Island Meeting on von Willebrand Disease

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila   +17 more
wiley   +1 more source

The Role of Factor XI in a Dilute Thromboplastin Assay of Extrinsic Coagulation Pathway

open access: yes, 2001
SummaryBlood coagulation has been thought to be composed of both intrinsic and extrinsic pathways. Recent evidence strongly supports the critical role of the extrinsic pathway in the initiation of blood coagulation.
Juncheng Li   +6 more
core   +1 more source

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