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Thromboplastin as a Reagent

Thrombosis and Haemostasis, 1970
SummaryTissue thromboplastin is the key reagent in the one-stage prothrombin time test. To obtain reliable results, a potent thromboplastin with constant activity and stability is required. This need is met by acetone-dehydrated rabbit brain. This reagent, when protected against oxidation by sealing in an evacuated tube, retains its full activity ...
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The Inactivation of Plasma-Thromboplastin

Thrombosis and Haemostasis, 1958
Summary1. Anti-plasmathromboplastin activity is found in plasma and in serum.2. The anti-plasmathromboplastin activity was increased in the majority of patients with hemophilia A and B, with chronic idiopathic thrombocytopenia, uremia, and in the cases of obstetrical afibrinogenemia, obstructive jaundice and Morbus Addison examined.
E, DEUTSCH, E, MAMMEN
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The thermolability of tissue thromboplastins

Irish Journal of Medical Science, 1966
1. The thermolability of tissue thromboplastins is markedly increased in the presence of cysteine, glutathione sulphite and hydrosulphite, but not in the presence of cysteine, ascorbate, thiosulphate or thiocyanate. 2. Thermostability is increased by fluoride (and ageing), but is overcome by cysteine. 3.
W A, Boggust, R A, O'Meara
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Comparison of a Highly Sensitive Rabbit Brain Thromboplastin, Dade Thromboplastin FS, with a Human Brain Thromboplastin, Manchester Comparative Thromboplastin

1984
A few years ago, a field trial was carried out in which a large number of plasma samples (100 normals, 806 anticoagulated patients, as well as patients with deficiencies of the factors II, V, VII and X) were tested with a newly developed rabbit brain thromboplastin (Thromboplastin FS) and with Human Brain Thromboplastin prepared by Prof.
R. Spaethe, I. Shirley
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THROMBOPLASTIN REFERENCE PREPARATIONS

Scandinavian Journal of Haematology, 1980
The need for standardization of methods for the control of anticoagulant therapy was apparent 25 years ago. With the development of the ratio method for comparing the sensitivity of different thromboplastin preparations it became possible to equate the value obtained with one preparation in terms of the value which would be obtained with any other ...
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Plasma Thromboplastin Antecedent

A.M.A. Archives of Internal Medicine, 1955
Until recently, male persons with a severe hemorrhagic diathesis characterized by (1) a prolonged clotting time, (2) normal Quick plasma prothrombin time, but (3) a poor prothrombin consumption were unhesitatingly diagnosed as suffering from classic hemophilia.
B, RAMOT, B, ANGELOPOULOS, K, SINGER
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Thromboplastin Generation Test

JAMA: The Journal of the American Medical Association, 1967
In the classical theory of blood coagulation, it was postulated that prothrombin was converted to thrombin through the action of calcium and thromboplastin. It is now established that circulating blood contains no active thromboplastin but that thromboplastin is generated during coagulation.
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[Variability of INR due to thromboplastin. Comparison of two recombinant thromboplastins and one rabbit thromboplastin].

Annales de biologie clinique, 1996
We have compared the INR obtained with three different thromboplastin reagents: one rabbit and two recombinant tissue factor thromboplastins using the same coagulometer. A preliminary study has shown that freezing of plasmas at -80 degrees centigrade causes a 6% increase in INR.
J L, Renier   +2 more
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[Comparison of a sensitive rabbit brain thromboplastin and a human placenta thromboplastin for thromboplastin time determination].

Schweizerische medizinische Wochenschrift, 1989
Prothrombin times were measured in 120 orally anticoagulated patients and 122 patients not orally anticoagulated using two different commercial thromboplastin reagents, a rabbit brain thromboplastin (CRB-Thromboplastin, Roche) and a human placenta thromboplastin (Thromborel S, Behring).
B, Lämmle, M, Furlan, I, Sulzer
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Reappraisal of thromboplastin.

Annals of clinical and laboratory science, 1981
Proficiency testing surveys in the state of New York indicate that despite increased sophistication in instrumentation, there has been no real improvement in interlaboratory reproducibility in prothrombin-time determinations over the last 10 years. This lack of improvement most pronounced in the therapeutic range of 20 to 30 sec. One reason may be that
F D, Ziegler   +4 more
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