Results 61 to 70 of about 7,460 (217)
Small, EarlyView.We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo +13 more
wiley +1 more source
Cancer Medicine, 2019 Methods to deepen clinical responses to ibrutinib are needed to improve outcomes for patients with chronic lymphocytic leukemia (CLL). This study aimed to determine the safety and efficacy of combining a janus kinase (JAK)‐inhibitor with ibrutinib ...
David E. Spaner +4 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2021 Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a ...
Ryosuke Shimizu +2 more
doaj +1 more source
Vaccines, 2022 Erythropoiesis and megakaryo-/thrombopoiesis occur in the bone marrow proceeding from common, even bipotent, progenitor cells. Recently, we have shown that protective vaccination accelerates extramedullary hepatic erythroblastosis in response to blood ...
Frank Wunderlich +3 more
doaj +1 more source
CK2: a key regulator of thrombopoiesis [PDF]
Blood, 2017 In this issue of Blood, Munzer et al used a specific platelet/megakaryocyte (MK) deletion of casein kinase (CK) 2β mouse model to elegantly demonstrate that CK2 regulates both platelet formation and activation by altering microtubule structure, which results in impaired intracellular Ca2+ release ...
William, Vainchenker, Hana, Raslova
openaire +2 more sources
Expression of Regulatory Platelet MicroRNAs in Patients with Sickle Cell Disease [PDF]
, 2013 Background: Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications.
A Abdollahi +71 more
core +3 more sources
Small Structures, Volume 7, Issue 3, March 2026.This review summarizes advances in bone organoid research over the last 5 years, addressing their definition, distinctive characteristics, construction methods, and applications. It highlights pivotal technologies, contrasts organoid‐based platforms with conventional regeneration methodologies, and explores emerging directions. By recapitulating native
Le Xiao +12 more
wiley +1 more source
Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice [PDF]
, 2008 Background Interleukin-12 (IL-12) is a cytokine well known for its role in immunity. A lesser known function of IL-12 is its role in hematopoiesis. The promising data obtained in the preclinical models of antitumor immunotherapy raised hope that IL-12 ...
Lena A Basile +69 more
core +2 more sources
Clinical Case Reports, Volume 14, Issue 2, February 2026.Diffuse petechiae and non‐palpable purpura (lower extremities below knee, admission photo). ABSTRACT Immune thrombocytopenia (ITP) is a rare but recognized hematologic complication of tuberculosis (TB), particularly miliary TB. We present a case of a 50‐year‐old female with severe thrombocytopenia and hemorrhagic manifestations secondary to miliary TB.
Hayatu Awel Abdela +3 more
wiley +1 more source
Thrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells
Scientific Reports, 2023 The use of megakaryoblastic leukemia MEG-01 cells can help reveal the mechanisms of thrombopoiesis. However, conventional in vitro activation of platelet release from MEG-01 cells requires thrombopoietin, which is costly.
Nuntiporn Nunthanasup +6 more
doaj +1 more source