Results 21 to 30 of about 15,364 (179)

Severe Clinical Course in a Patient with Congenital Amegakaryocytic Thrombocytopenia Due to a Missense Mutation of the c-MPL Gene

Turkish Journal of Hematology, 2015
Congenital amegakaryocytic thrombocytopenia (CAMT) generally begins at birth with severe thrombocytopenia and progresses to pancytopenia. It is caused by mutations in the thrombopoietin receptor gene, the myeloproliferative leukemia virus oncogene (c-MPL)
İkbal Ok Bozkaya, Neşe Yaralı, Pamir Işık, Rukiye Ünsal Saç, Betül Tavil, Bahattin Tunç   +5 more
doaj   +1 more source

A novel recombinant human thrombopoietin for treating prolonged isolated thrombocytopenia after allogeneic stem cell transplantation

Platelets, 2019
Patients with prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) are known to have a poor prognosis. However, there is no standard treatment for PT.
Yu-Qian Sun, Yuan Kong, Xiao-Hui Zhang, Yu Wang, Min-Min Shi, Yang Song, Jun Kong, Hai-Xia Fu, Chen-Hua Yan, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang   +11 more
doaj   +1 more source

D-dencichine Regulates Thrombopoiesis by Promoting Megakaryocyte Adhesion, Migration and Proplatelet Formation

Frontiers in Pharmacology, 2018
Life-threatening chemotherapy-induced thrombocytopenia can increase the risk of bleeding due to a dramatic low platelet count, which may limit or delay treatment schedules in cancer patients. The pressing need for the rapid alleviation of the symptoms of
Shilan Ding, Shilan Ding, Shilan Ding, Shilan Ding, Min Wang, Min Wang, Min Wang, Min Wang, Song Fang, Huibo Xu, Huiting Fan, Yu Tian, Yu Tian, Yu Tian, Yu Tian, Yadong Zhai, Yadong Zhai, Yadong Zhai, Yadong Zhai, Shan Lu, Shan Lu, Shan Lu, Shan Lu, Xin Qi, Fei Wei, Fei Wei, Fei Wei, Fei Wei, Guibo Sun, Guibo Sun, Guibo Sun, Guibo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun   +35 more
doaj   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Correction of Thrombocytopenia with Thrombopoietin Receptor Agonists in Patients with Liver Cirrhosis Before Elective Surgery or Invasive Procedures

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to review the pathogenesis of thrombocytopenia and possible ways of its correction in patients with liver cirrhosis before elective surgical interventions or invasive procedures to optimize clinical practice.Key points.
T. A. Deeva, M. V. Maevskaya, V. T. Ivashkin   +2 more
doaj   +1 more source

Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma

Diagnostics, 2022
Plasma thrombopoietin (TPO) measurements help distinguish between different types of thrombocytopenia but are not feasible in routine clinical practice. We developed a fully automated quantitative chemiluminescent enzyme immunoassay (CLEIA) for measuring
Yukihiro Nishikawa, Shiyo Nishida, Keiko Kuroda, Hirokazu Kashiwagi, Yoshiaki Tomiyama, Masataka Kuwana   +5 more
doaj   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

A new mouse model of thrombopoietin deficiency arising from a spontaneous single base pair mutation

Platelets
Thrombopoietin (TPO) is the principal regulator of bone marrow platelet production and plays an important role in maintaining hematopoietic stem and progenitor cells.
Nan Sophia Han, Emma E. Yvanovich, Shenglin Mei, Harvey G. Roweth, Elisabeth M. Battinelli, David B. Sykes, Ninib Baryawno   +6 more
doaj   +1 more source

Intrahospital switch of the P2Y12 inhibitors in patients with ST segment elevation myocardial infarction in ‘real-life’ clinical practice: the effect on the functional activity of thrombocytes and thrombocytopoiesis, prognostic value

Кардиоваскулярная терапия и профилактика, 2019
Aim. To assess the P2Y12 inhibitors switch in patients ST segment elevation myocardial infarction (STEMI) in real-life’ clinical practice, evaluate the functional activity of thrombocytes and thrombocytopoiesis and determine the clinical and prognostic ...
L. I. Malinova, P. V. Dolotovskaya, N. F. Puchinyan, V. V. Furman   +3 more
doaj   +1 more source

Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?

Open Medicine, 2022
A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis.
Herczeg Gyorgy, Somogyi Aniko, Herold Magdolna, Fodor Agnes, Rosta Klara, Dank Magdolna, Lang Zsolt, Herold Zoltan   +7 more
doaj   +1 more source