Results 51 to 60 of about 15,364 (179)

Platelet Levels Associated With Bleeding Risk for Dental Interventions: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objectives To evaluate evidence in relation to postoperative bleeding in humans aged ≥ 16 with preoperative platelet counts < 50,000/μL, compared to those above, undergoing dental interventions. Methods Quantitative synthesis without meta‐analysis was conducted through an electronic search conducted on Ovid MEDLINE and Embase from 1946 to ...
Guang Xu David Lim, Fatima Al Sarraf, Hana Cho, Navdeep Kumar   +3 more
wiley   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol‐Inspired Approach

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Tianyi Yu, Cheng Wang, Jingru Xie, Yongxin Wei, Hongwei Cui, Huaxia Zhang, Fan Zhou, Zhendong Deng, Ye Yang, Chunyan Gu   +9 more
wiley   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, Volume 101, Issue 4, Page 697-709, April 2026.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

Successful Haplo‐Hematopoietic Stem Cell Transplantation for Juvenile Myelomonocytic Leukemia in a Child With Underlying Thrombocytopenia‐Absent Radius Syndrome: A Unique Case

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Thrombocytopenia‐absent radius (TAR) syndrome is a rare congenital disorder characterized by bilateral radial aplasia with preserved thumbs and early‐onset thrombocytopenia. While hematologic and skeletal abnormalities define the condition, its association with hematologic malignancies is extremely rare, with only a few reported ...
Sondus Al Sharidah, Ahmed Elhussien, Walid I. A. Soliman, Nesma I. Ellithy   +3 more
wiley   +1 more source

Idiopathic thrombocytopenic purpura: laboratory diagnosis and management

Universa Medicina, 2016
Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease characterized by low platelet count (
Alvina Alvina
doaj   +1 more source

Successful Treatment of Aplastic Anemia With Eltrombopag During Pregnancy: A Short Report

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Aplastic anemia (AA) is a rare bone marrow failure syndrome with pancytopenia, mainly due to immune‐mediated stem cell destruction. First‐line therapy for acquired severe AA ≥ 50 years/non‐severe AA (NSAA) requiring treatment is immunosuppressive therapy with horse anti‐thymocyte globulin, cyclosporine A (CSA), and eltrombopag ...
Sandra M. Frey, Ferras Alashkar, H. Christian Reinhardt, Alexander Röth   +3 more
wiley   +1 more source

Fostamatinib treatment for patients with antiphospholipid syndrome and low platelet count: A case series

British Journal of Haematology, EarlyView.
Ekaterina Balaian, Rosa Sonja Alesci, Sandra Marten, Julia‐Annabell Georgi, Christiane Naue, Martin Bornhäuser, Karolin Trautmann‐Grill   +6 more
wiley   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Age‐Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function

Aging Cell, Volume 25, Issue 4, April 2026.
GADD45B knockout in hematopoietic stem cells causes DNA methylation changes that mirror some age‐associated patterns but don't affect HSC function or gene expression. We created a searchable database to identify consistently reported methylation sites associated with age‐related HSC functional decline.
Wakako Kuribayashi, Mayuri Tanaka‐Yano, Bongsoo Park, Hagai Yanai, Ferda Tekin‐Turhan, Isabel Beerman   +5 more
wiley   +1 more source

The Low Platelet Count at the Start of Atezolizumab Plus Bevacizumab Therapy for Unresectable Hepatocellular Carcinoma Predicts Deteriorated Liver Function at the Time of Disease Progression Thereafter: A Multicenter Analysis

Hepatology Research, Volume 56, Issue 4, Page 573-581, April 2026.
The platelet count can be used to predict liver function at the time of evaluation of progressive disease (PD) after atezolizumab plus bevacizumab (ATZ/BEV) therapy in patients with u‐HCC. Treatment strategies in u‐HCC patients with low platelet counts should be conducted by taking into account deterioration of liver function after ATZ/BEV.
Ryo Sato, Takanori Suzuki, Kentaro Matsuura, Daisuke Kato, Katsumi Hayashi, Kohei Okayama, Fumihiro Okumura, Satoshi Sobue, Atsunori Kusakabe, Izumi Hasegawa, Kiyoto Narita, Tsutomu Mizoshita, Yoshihide Kimura, Hiromu Kondo, Hisayo Kojima, Kazuki Hayashi, Atsushi Ozasa, Hayato Kawamura, Kei Fujiwara, Shunsuke Nojiri, Hiromi Kataoka, Sakurayama Liver Study Group (SLSG)   +21 more
wiley   +1 more source