Results 81 to 90 of about 19,999 (193)

A network map of thrombopoietin signaling

, 2018
Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a cytokine involved in the production of platelets. THPO is a glycoprotein produced by liver and kidney.
Chakrabarti, Prantar, Chatterjee, Aditi, Bhat, Firdous A., Khan, Aafaque Ahmad, Mohan, Sonali, Prasad, T. S. Keshava, Pal, Arnab, Advani, Jayshree, Gowda, Harsha   +8 more
core   +1 more source

Trace of chestnut on platelets proliferation in male rats: In vivo study [PDF]

Iraqi Journal of Veterinary Sciences
The study seeks the efficacy of the chestnut extract on platelet proliferation and its function in guaranteeing more tangible physiological information about unexpected mortality caused by thrombus formation.
Hiyam N. Maty
doaj   +1 more source

Severe Thrombocytopenia Associated With Glucagon‐Like‐1 Receptor Agonists (GPL‐1RA): A SONAR Report

Diabetes, Obesity and Metabolism, EarlyView.
Charles L. Bennett, Chadi Nabhan, Demir Uslu, Yogitha Dadi, David Aboulafia, Barbara Senger, Joseph Magagnoli, Kelvin Rojas, Gurdeep Singh, Linda Martin, Edward Smith, Samuel Ruder, Chien‐Hsiang Weng, Nikhil Uppal, Mia Lynch, James B. Bussel   +15 more
wiley   +1 more source

Post-Exposure JNJ-26366821 Treatment Attenuates Systemic Inflammation and Limits Cardiotoxic Risk

Biomolecules
Introduction: Thrombopoietin mimetics (TPOm) are known to increase blood cell counts, thereby ameliorating various diseases, including cardiomyopathy—a leading cause of mortality because of delayed radiotoxic effects.
Nabarun Chakraborty, Gregory P. Holmes-Hampton, Lily S. Neff, Vidya P. Kumar, Swapna Kannan, Amrita K. Cheema, Chandan Guha, Sanchita P. Ghosh, Rasha Hammamieh   +8 more
doaj   +1 more source

Reversible Eltrombopag‐Associated Bone Marrow Fibrosis With Hematologic Recovery After Drug Withdrawal in ASXL1‐Mutated Hypoplastic Myelodysplastic Syndrome: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Hypoplastic myelodysplastic syndrome (MDS) often overlaps clinically with aplastic anemia and frequently involves clonal hematopoiesis. Thrombopoietin receptor agonists (TPO‐RAs), including eltrombopag, are increasingly used to treat cytopenias in hypoplastic marrow failure syndromes; however, their long‐term effects on clonal dynamics and ...
Kyoko Yoshihara, Ikuo Matsuda, Yasuhito Nannya, Mami Samori, Naru Tomigaki, Saki Takahashi, Chisato Ohe, Satoshi Yoshihara   +7 more
wiley   +1 more source

Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway

Asian Pacific Journal of Tropical Biomedicine
Objective: To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1 (SIRT1) signaling pathway.
Xu-Han Zuo, Yu Huang, Bo-Cen Chen, Ming-Yue Zhu, Cai-Cai Zhang, Han-Yi Jiao, Li-Fang Lu, Man Xiao, Han Wang   +8 more
doaj   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Chronic liver disease, thrombocytopenia and procedural bleeding risk; are novel thrombopoietin mimetics the solution?

Platelets, 2019
Chronic liver disease (CLD) alters normal hemostatic and thrombotic systems via multiple mechanisms including reduced platelet function and number, leading to challenging peri-operative planning.
Sven R. Olson, Steven Koprowski, Justine Hum, Owen J.T. McCarty, Thomas G. DeLoughery, Joseph J. Shatzel   +5 more
doaj   +1 more source

Dietary CoQ10 Ameliorates Age‐Related Megakaryocyte Dysfunction via COPS3‐Mediated Activation of Autophagy

Aging Cell, Volume 25, Issue 10, October 2026.
Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Yixuan Xu, Yu‐heng Mao, Fenglin Song, Fang He, Yueying Wu, CaiXia Wang, Minghan Wang, Shuangfeng Xie, Heyu Ni, Yan Yang   +9 more
wiley   +1 more source

Pharmacoeconomic Analysis of the Use of Thrombopoietin Receptors Agonists in Idiopathic Thrombocytopenic Purpura Therapy [PDF]

, 2017
Background. New medications, thrombopoietin mimetics which were recently introduced into clinical practice allowed to achieve clinical response in patients with chronic glucocorticoid-resistant idiopathic thrombocytopenic purpura (ITP). However, the high
S.V. Voloshin, Vasilii Anatol’evich Shuvaev, A. K. Hadzhidis, A. V. Chechetkin, A.K. Hadzhidis, Vasilii Anatol'evich Shuvaev, S. V. Voloshin, A.V. Chechetkin   +7 more
core   +1 more source