Results 91 to 100 of about 19,999 (193)

Eltrombopag can promote platelet implantation after allogeneic hematopoietic stem cell transplantation as safely and similarly to thrombopoietin

Frontiers in Immunology
BackgroundEltrombopag has demonstrated efficacy in treating low platelet (PLT) levels, but it remains unclear whether eltrombopag can promote PLT engraftment after hematopoietic stem cell transplantation (HSCT).MethodsForty-one HSCT patients received ...
Yahan Li, Fansheng Kong, Guanchen Bai, Yujie Jiang, Wenlu Zhang, Xue Sun, Xiaohui Sui, Ying Li, Mei Ding, Dai Yuan, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xiaosheng Fang   +14 more
doaj   +1 more source

Romiplostim for treatment of thrombocytopenia in dogs: A retrospective assessment and clinical outcomes

Journal of Veterinary Internal Medicine
Background Romiplostim, a thrombopoietin analog, is commonly used to treat immune‐mediated thrombocytopenia (ITP) in humans, but its use in dogs remains limited.
Min‐Ok Ryu, Jin‐Kyung Kim, Ju‐Hyun An, Kyoung‐Won Seo, Ye‐In Oh, Hwa‐Young Youn   +5 more
doaj   +1 more source

Avatrombopag for persistent and chronic immune thrombocytopenia in children: A post hoc analysis of clinical characteristics of response from a phase 3b clinical trial

British Journal of Haematology, Volume 209, Issue 4, Page 1818-1827, October 2026.
Summary Avatrombopag treatment resulted in significantly higher platelet response rates in patients when compared with placebo in a phase 3b study of patients with paediatric immune thrombocytopenia (ITP) (NCT04516967). These post hoc analyses of the 12‐week core phase further assessed the efficacy of avatrombopag, considering the influence of baseline
Rachael F. Grace, Göksel Leblebisatan, Yesim Aydinok, Sule Unal, John Grainger, Amanda B. Grimes, Michele P. Lambert, Jessica Zhang, Brian D. Jamieson, Faizan Sattar, Scott Kolodny, Michael Vredenburg, on behalf of the AVA‐PED‐301 Study Group   +12 more
wiley   +1 more source

Orientation-specific signalling by thrombopoietin receptor dimers.

, 2011
Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte differentiation and platelet formation, as well as haematopoietic stem cell renewal.
Smith, Steven O, Emilie Leroy, Jean-Philippe Defour, Judith Staerk, William Vainchenker, Pecquet, Christian, Brett, Ian, Defour, Jean-Philippe, Leroy, Emilie, Miki Itaya, Vainchenker, William, Steven O Smith, Staerk, Judith, Stefan N Constantinescu, Constantinescu, Stefan N., Christian Pecquet, Hélène Antoine-Poirel, Poirel, Hélène, Ian Brett, Itaya, Miki   +19 more
core   +1 more source

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.

, 2020
The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it ...
Zhizhuang J Zhao, Donna M Williams, Alison R Moliterno, Wanke Zhao, Akil Merchant, Ophelia Rogers, Linda S Resar, Amy Duffield, Jerry L Spivak   +8 more
core   +1 more source

Identification of MPL R102P Mutation in Hereditary Thrombocytosis

Frontiers in Endocrinology, 2017
The molecular basis of hereditary thrombocytosis is germline mutations affecting the thrombopoietin (TPO)/TPO receptor (MPL)/JAK2 signaling axis. Here, we report one family presenting two cases with a mild thrombocytosis.
Christine Bellanné-Chantelot, Christine Bellanné-Chantelot, Matthieu Mosca, Matthieu Mosca, Matthieu Mosca, Caroline Marty, Caroline Marty, Caroline Marty, Rémi Favier, Rémi Favier, William Vainchenker, William Vainchenker, William Vainchenker, Isabelle Plo, Isabelle Plo, Isabelle Plo   +15 more
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, Volume 209, Issue 4, Page 1482-1485, October 2026.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Platelet dysfunction: status of thrombopoietin in thrombocytopenia associated with chronic liver failure

, 2015
Thrombocytopenia is a common hematological abnormality in patients with chronic liver disease, and its prevalence is higher in patients with liver failure.
GIANNINI, EDOARDO GIOVANNI, Peck Radosavljevic M.   +1 more
core   +1 more source

Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era

British Journal of Haematology, Volume 209, Issue 4, Page 1715-1724, October 2026.
Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda, Eduardo Arellano‐Rodrigo, Manuel Pérez‐Encinas, José‐María Raya, María‐Teresa Gómez‐Casares, Francisca Ferrer‐Marín, Alberto Hernández‐Sánchez, María‐Laura Fox, Anna Angona, Beatriz Cuevas, María‐Isabel Mata‐Vázquez, Rosa Ayala, Natalia de las Heras, Elvira Mora, Valentín García‐Gutiérrez, Alicia Senín, Jasson Villarreal, Blanca Xicoy, Raúl Pérez‐López, María García‐Fortes, Sonia González de Villambrosia, Elena Magro, María‐José Ramírez, Paula Gómez, Angel Ramírez‐Payer, Clara Martínez‐Valverde, Lucía Pérez‐Lamas, Carmen García‐Hernández, Mercedes Gasior, Luis‐Miguel Juárez‐Salcedo, Francisco Ibáñez, María‐Luisa Antelo, Lucía Guerrero, Alberto Alvarez‐Larrán, Arturo Pereira, on behalf of the Spanish MPN Group (GEMFIN)   +35 more
wiley   +1 more source

Thrombopoietin: A novel candidate tumor marker for the diagnosis of ovarian cancer

, 2012
Objective: To investigate the decisive role of preoperative serum thrombopoietin levels in the discrimination of benign and malignant ovarian pathologies and its value in the evaluation of treatment response.
Zeybek B., Zekioglu O., Terek M.C., Ergenoglu A.M., Ozsaran A., Mermer T., Yeniel A.O.   +6 more
core   +1 more source