Results 91 to 100 of about 15,012 (140)
Some of the next articles are maybe not open access.
Thrombopoietin and Thrombopoietin Mimetics in the Treatment of Thrombocytopenia
Annual Review of Medicine, 2009Although the thrombopoietin receptor was discovered in 1991 and thrombopoietin (TPO) was purified in 1994, the development of a clinically useful TPO was hampered by the appearance of neutralizing antibodies to some forms of recombinant TPO. However, in 2008 two new drugs that mimic the effect of TPO became available to treat thrombocytopenia ...
openaire +2 more sources
Structure of Thrombopoietin and the Thrombopoietin Gene
1997The cloning of thrombopoietin (TPO) has been a significant advance for several fields of scientific inquiry. In addition to enabling the production of recombinant TPO, the cloning of TPO cDNA also facilitates examination of TPO itself, a hemopoietic cytokine with unique structural features.
Austin L. Gurney, Frederic J. de Sauvage
openaire +1 more source
2010
Megakaryopoiesis and thrombopoiesis are the central biological processes of platelet generation. Severe thrombocytopenia is a major morbidity and mortality factor in several diseases and represents a significant unmet medical need. Since the discovery of thrombopoietin (TPO) as the primary physiological regulator of megakaryopoiesis, a number of ...
openaire +2 more sources
Megakaryopoiesis and thrombopoiesis are the central biological processes of platelet generation. Severe thrombocytopenia is a major morbidity and mortality factor in several diseases and represents a significant unmet medical need. Since the discovery of thrombopoietin (TPO) as the primary physiological regulator of megakaryopoiesis, a number of ...
openaire +2 more sources
Haemostasis, 2009
The regulator of platelet count is believed to be thrombopoîetin (mpl ligand). It is thought to act on the megakaryocytic lineage affecting the proliferation of committed cells, the maturation of megakaryocytes and the blood platelet levels by activation of its receptor (the c-mpl). Recently, it has been purified and sequenced.
openaire +1 more source
The regulator of platelet count is believed to be thrombopoîetin (mpl ligand). It is thought to act on the megakaryocytic lineage affecting the proliferation of committed cells, the maturation of megakaryocytes and the blood platelet levels by activation of its receptor (the c-mpl). Recently, it has been purified and sequenced.
openaire +1 more source
Thrombopoietin — Clinically Realized?
New England Journal of Medicine, 1997For approximately 30 years, hematologists have sought the humoral regulator of platelet production, thrombopoietin.1 Although a factor with the appropriate physiologic effects was partially purifie...
openaire +2 more sources
Protein Characteristics of Thrombopoietin
Stem Cells, 1996Thrombopoietin (TPO) was purified from irradiated thrombocytopenic rat plasma. In the process of purification, some biochemical and biological characteristics were investigated. Rat plasma TPO was extremely hydrophobic and exhibited multiple peaks of activity on gel filtration.
openaire +2 more sources
The thrombopoietin receptor: revisiting the master regulator of platelet production
Platelets, 2021Ian Hitchcock +2 more
exaly