Results 101 to 110 of about 19,999 (193)

The end of a long search: at last thrombopoietin.

, 1994
Editorial on the discovery of the thrombopoietin ...
CAZZOLA, MARIO
core  

Effect of efgartigimod IV on immature platelet fraction in primary immune thrombocytopenia in the ADVANCE IV trial

British Journal of Haematology, Volume 209, Issue 4, Page 1932-1936, October 2026.
Elevated percentage of immature platelets is indicative of consumptive thrombocytopenic disorders. In immune thrombocytopenia, low platelet counts may result from reduced production or increased degradation, both driven by IgG autoantibodies. By blocking FcRn, efgartigimod decreases immature platelet fraction, likely by reducing platelet degradation ...
Hanny Al‐Samkari, Filip Matthijssens, Kaichi Nishiwaki, Francesco Zaja, Sylvian Audia, Yoshitaka Miyakawa, Jaume Ayguasanosa, Damien Chimits, Anna Hultberg, Peter Ulrichts   +9 more
wiley   +1 more source

Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation

, 1999
BACKGROUNDThrombocytopenia in cirrhotic patients may be due to deficient production of thrombopoietin.AIMSTo determine the relation between thrombopoietin and thrombocytopenia in cirrhotic patients before and after orthotopic liver transplantation ...
T N Chau, S Jordan, A K Burroughs, A Watkinson, J Goulis, A B Mehta, K Rolles   +6 more
core   +1 more source

Systemic inflammation and prognosis in patients with RAS/BRAF wild‐type metastatic colorectal cancer receiving anti‐EGFR therapy: A real‐world cohort study

Colorectal Disease, Volume 28, Issue 10, October 2026.
Abstract Aim Colorectal cancer outcomes are heterogeneous, so greater prognostic discrimination is needed. In this retrospective real‐world analysis, we assessed the prognostic effect of markers of systemic inflammation in a cohort of patients with RAS/BRAF wild‐type metastatic colorectal cancer (mCRC) who received anti‐EGFR therapy during routine care.
Jordan W. Appleyard, Faye Elliott, Nancy L. Sapanara, Liping Zhang, Uday Kurkure, Jenny F. Seligmann, Nicholas P. West, Kandavel Shanmugam, Philip Quirke, Christopher J. M. Williams, on behalf of the N6 Collaboration   +10 more
wiley   +1 more source

Determination of interactions between human thrombopoietin and its receptor MPL by yeast two-hybrid system and affinity biosensor

, 2000
The binding of human thrombopoietin to the extracellular domain of its receptor MPL prompts a cascade transduction of intracellular signals, leading to the development of megakaryocyte precursors and the production of circulating platelets.
Tsang, PWK, Paul W.K. Tsang, Hsieh, Dennis P.H., Dennis P.H. Hsieh, J. Wang, Huxtable, Susan, Huxtable, S, Xu, Peilin, Huih Min Chen, Wang, J., Hsieh, DPH, Peilin Xu, Kit Fong Ng, Ng, KF, Wang, J, Xu, P, Chen, Huih Min, Chen, HM, Ng, Kit Fong, Susan Huxtable, Tsang, Paul W.K.   +20 more
core   +1 more source

Haematopoietic Cells Deficient for Calreticulin or Expressing Its Oncogenic Variants Maintain Functional Antigen Presentation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Intact antigen presentation in cancer cells is a key prerequisite for endogenous anticancer T cell responses and a starting point for immunotherapy. Calreticulin was postulated as a chaperone and integral part of the peptide‐loading complex of MHC‐I.
Maria Höhrhan, Laura Antonio‐Herrera, Henrique G. Colaço, Anja Wagner, Markus Unterwurzacher, Cecilia Varga, Klaus Kratochwill, Andreas Bergthaler, Robert Kralovics   +8 more
wiley   +1 more source

Pure erythroid leukaemia in early infancy: Diagnostic pitfalls and clinical challenges

British Journal of Haematology, Volume 209, Issue 4, Page 1442-1443, October 2026.
Riccardo De Carli, Baptiste Le Calvez, Elodie Lainey, Catherine Settegrana, Marion Strullu, Marlene Pouthier   +5 more
wiley   +1 more source

Reticulated platelets and thrombopoietin in schistosomiasis patients

, 2009
Schistosomiasis mansoni is a non-cirrhotic liver disease. in cirrhosis patients with portal hypertension, a decreased number of reticulated platelets associated with increased thrombopoietin serum levels were reported.
D. R. BORGES, Lourenco, D. M., L. A. KÖPKE‐AGUIAR, D. M. LOURENÇO, Borges, D. R., C. P. DE LEON, Shigueoka, D. C., Kouyomdjian, M., M. KOUYOMDJIAN, D. C. SHIGUEOKA, Koepke-Aguiar, L. A., dE Leon, C. P.   +11 more
core   +1 more source

Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients

, 2004
Objective: To measure serum thrombopoietin levels and to investigate their relationship with platelet counts and other potential determinants in septic patients. Design: Prospective study comparing septic patients and healthy volunteers. Setting: General
Theodoridis, T, Zakynthinos, SG, EG, Papanikolaou, S, Christopoulou-Kokkinou, V, Mavrommatis, AC, Zakynthinos, Katsaris, G   +7 more
core   +1 more source

Long‐term efficacy and safety of romiplostim plus immunosuppressive therapy as first‐line treatment in patients with aplastic anaemia: 2‐year interim analysis of observational study of two clinical trials

British Journal of Haematology, Volume 209, Issue 4, Page 1955-1959, October 2026.
Jong Wook Lee, Kohei Hosokawa, Jun Ho Jang, Naoshi Obara, Masashi Sawa, Kensuke Usuki, Gaku Oshikawa, Masahiro Kizaki, Koji Nagafuji, Ting‐An Lin, Hitoshi Hanamoto, Yeung‐Chul Mun, Toshiro Kawakita, Kazunori Imada, June‐Won Cheong, Sung‐Soo Park, Takayuki Tabayashi, Masaru Gamou, Kenta Murotani, Hirohito Yamazaki   +19 more
wiley   +1 more source