Results 81 to 90 of about 775,077 (341)

P1689: TISSUE-SELECTIVE PHARMACOLOGICAL TARGETING OF TUMOR INTRINSIC PROTHROMBIN (F2) EXPRESSION USING AN INTEGRATED GENETIC REPORTER SYSTEM

HemaSphere, 2022
E. Khan, J. Nourse, S. Tokalov, S. Khokhar, D. Arnold-Schild, L. Schott, L. Eder, S. Danckwardt   +7 more
doaj   +1 more source

Effectiveness and Safety of Apixaban for Treatment of Venous Thromboembolism in Daily Practice

TH Open, 2020
Introduction Phase 3 trials have shown comparable efficacy of direct oral anticoagulants (DOACs) and vitamin K antagonists in patients with acute venous thromboembolism (VTE), with less major bleeding events in patients randomized to DOAC treatment. With
Stephan V. Hendriks, Frederikus A. Klok, Wilhelmina J.E. Stenger, Albert T.A. Mairuhu, Jeroen Eikenboom, Jaap Fogteloo, Menno V. Huisman   +6 more
doaj   +1 more source

Poly(hydroxy‐oxazolidone) Thermoplastic Elastomers for Safer, Greener and Customizable Blood‐Contacting Medical Devices

Advanced Healthcare Materials, EarlyView.
A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo, Anna Pierrard, Fréderic Lifrange, Marco Caliari, Céline D'Emal, Margaux Debuisson, Haritz Sardon, Philippe Delvenne, Patrizio Lancellotti, Christophe Detrembleur, Christine Jérôme, Cécile Oury   +11 more
wiley   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Efficacy and safety of mechanical pulmonary valve replacement: a comprehensive systematic review and meta-analysis

Journal of Cardiothoracic Surgery
Background Pulmonary valve replacement (PVR) is the most common valve replacement procedure for pulmonary valve dysfunction in congenital heart diseases (CHD).
Ali Rafati, Sina Rashedi, Yeganeh Pasebani, Milad Vahedinejad, Hamed Ghoshouni, Yaser Toloueitabar, Mostafa Mousavizadeh, Sedigheh Saedi, Amirhosein Jalali, Zahra Khajali, Hassan Tatari, Fahimeh Farrokhzadeh, Hooman Bakhshandeh, Maziar Gholampour Dehaki, Behshid Ghadrdoost, Parham Sadeghipour   +15 more
doaj   +1 more source

The Central role of KNG1 gene as a genetic determinant of coagulation pathway-related traits: Exploring metaphenotypes [PDF]

, 2016
Traditional genetic studies of single traits may be unable to detect the pleiotropic effects involved in complex diseases. To detect the correlation that exists between several phenotypes involved in the same biological process, we introduce ...
Brunel, Helena, Martin-Fernandez, Laura, Martinez Perez, Angel, Massanet, Raimon, Perera Lluna, Alexandre, Soria, José Manuel, Souto, Juan Carlos, Ziyatdinov, Andrey   +7 more
core   +4 more sources

Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR‐Chemiluminescence Imaging

Advanced Materials, EarlyView.
AIE‐active tetranuclear Ir(III) complex Ir‐4 as a sonosensitizer/sonocatalyst is formulated into a nanoplatform with an H2S donor. Ir‐4@S‐R NPs achieves combined endogenous NIR chemiluminescence imaging, sonodynamic therapy and release of H2S in situ by a bioorthogonal sonocatalytic reaction in vivo, achieving safe thrombolysis and anti‐inflammatory ...
Zihan Wu, Liping Zhang, Ziwei Wang, Shengnan Liu, Qiaohua Zhang, Chunguang Shi, Yachao Wang, Gelin Xu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +11 more
wiley   +1 more source

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants [version 1; referees: 2 approved]

F1000Research, 2017
The direct oral anticoagulants (DOACs) have now supplanted vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE). The DOACs include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit ...
Jeffrey I. Weitz, Iqbal H. Jaffer, James C. Fredenburgh   +2 more
doaj   +1 more source

Spontaneous thrombosis in a post-traumatic Splenic pseudo-aneurysm. [PDF]

, 2010
Introduction: Splenic pseudo-aneurysm is an uncommon complication following splenic injury caused by blunt abdominal trauma. Pseudo-aneurysm is usually treated with splenic arterial embolisation.
Bux, Shaik Ismail, Mohamad Saini, Suraini   +1 more
core  

Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding

Advanced Materials, EarlyView.
Waxberry‐inspired branched‐silica nanogel can swiftly stop bleeding upon blue laser endoscopy for gastrointestinal hemostasis in the esophagus, stomach, and duodenum of mini‐pigs. Abstract Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention.
Ruijue Dan, Yu Huang, Shali Tan, Kaige Xu, Yuchen Zhang, Zhaohui Luan, Paipai Qi, Xingyue Zhang, Donghui Zhu, Wen Zhong, Chaoqiang Fan, Malcolm Xing, Shiming Yang   +12 more
wiley   +1 more source