Results 1 to 10 of about 59,043 (117)

Age and Sex Impact the Role of Thrombospondin‐2 and Thrombospondin‐5 in Response to Hindlimb Ischemia [PDF]

FASEB BioAdvances
Peripheral arterial disease progression to critical limb ischemia remains a significant burden in the aged, necessitating revascularization. Therapies to enhance neovascularization, such as angiogenesis or arteriogenesis, may provide an option for ...
Ashley A. Peters, Melissa Rangel, Corinne Bunn, Xuerong Wang, Irene Helenowski, Kristopher G. Maier, Vivian Gahtan   +6 more
doaj   +2 more sources

Evaluation of changes in plasma levels of MMP-8, MMP-13, and Thrombospondin 2 in patients with Osgood–Schlatter disease (OSD) [PDF]

Frontiers in Molecular Biosciences
IntroductionOsgood-Schlatter disease (OSD) is characterized by its relatively frequent occurrence and unknown pathomechanism. It mainly affects young athletes.
Monika Kulesza, Tomasz Guszczyn, Aleksandra Kicman, Rafał Marecki, Michał Stanisław Kicman, Sławomir Ławicki   +5 more
doaj   +2 more sources

Discrete Correlation Summation Clustering Reveals Differential Regulation of Liver Metabolism by Thrombospondin-1 in Low-Fat and High-Fat Diet-Fed Mice

Metabolites, 2022
Thrombospondin-1 (TSP1) is a matricellular protein with many important roles in mediating carcinogenesis, fibrosis, leukocyte recruitment, and metabolism.
Steven M. Bronson, Brian Westwood, Katherine L. Cook, Nancy J. Emenaker, Mark C. Chappell, David D. Roberts, David R. Soto-Pantoja   +6 more
doaj   +1 more source

Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1

Frontiers in Cell and Developmental Biology, 2021
The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli.
Verônica Morandi, Jim Petrik, Jack Lawler   +2 more
doaj   +1 more source

Altitude, Exercise, and Skeletal Muscle Angio-Adaptive Responses to Hypoxia: A Complex Story

Frontiers in Physiology, 2021
Hypoxia, defined as a reduced oxygen availability, can be observed in many tissues in response to various physiological and pathological conditions. As a hallmark of the altitude environment, ambient hypoxia results from a drop in the oxygen pressure in ...
Pierre Lemieux, Olivier Birot
doaj   +1 more source

Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity

Frontiers in Physiology, 2022
The skeletal muscle tissue can adapt to exercise and environmental stressors with a remarkable plasticity. Prolonged cold stress exposure has been associated to increased skeletal muscle capillarization.
Pierre Lemieux, Emilie Roudier, Olivier Birot   +2 more
doaj   +1 more source

Research progress on the role of thrombospondin 2 in malignant tumors [PDF]

Jichu yixue yu linchuang, 2023
Thrombospondin 2 (THBS2) is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors, receptors, matrix molecules or proteases on the extracellular matrix and cell surface. THBS2 can be activated by N6-methyladenosyl RNA
MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng
doaj   +1 more source

Deciphering Cell-Cell Communication in Abdominal Aortic Aneurysm From Single-Cell RNA Transcriptomic Data

Frontiers in Cardiovascular Medicine, 2022
Cell-cell communication coordinates cellular differentiation, tissue homeostasis, and immune responses in states of health and disease. In abdominal aortic aneurysm (AAA), a relatively common and potentially life-threatening vascular disease ...
Huan Yang, Elise DeRoo, Ting Zhou, Bo Liu, Bo Liu   +4 more
doaj   +1 more source

Angiogenic Secretion Profile of Valvular Interstitial Cells Varies With Cellular Sex and Phenotype

Frontiers in Cardiovascular Medicine, 2021
Angiogenesis is a hallmark of fibrocalcific aortic valve disease (CAVD). An imbalance of pro- and anti-angiogenic factors is thought to play a role in driving this disease process, and valvular interstitial cells (VICs) may act as a significant source of
Victoria Nelson, Vaidehi Patil, LaTonya R. Simon, Kelsey Schmidt, Chloe M. McCoy, Kristyn S. Masters, Kristyn S. Masters, Kristyn S. Masters   +7 more
doaj   +1 more source

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Frontiers in Immunology, 2017
ObjectiveAssuming that mesenchymal stem cells (MSCs) respond to the osteoarthritic joint environment to exert a chondroprotective effect, we aimed at investigating the molecular response setup by MSCs after priming by osteoarthritic chondrocytes in ...
Marie Maumus, Marie Maumus, Cristina Manferdini, Karine Toupet, Karine Toupet, Paul Chuchana, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Mélanie Gachet, Christian Jorgensen, Christian Jorgensen, Christian Jorgensen, Gina Lisignoli, Danièle Noël, Danièle Noël, Danièle Noël   +16 more
doaj   +1 more source