Results 21 to 30 of about 78,453 (329)
Thrombospondin 1, thrombospondin 2 and the eye
Progress in Retinal and Eye Research, 2006 Thrombospondin 1 and thrombospondin 2 (TSP1 and TSP2), which comprise the subgroup A thrombospondins, are matricellular proteins. As matricellular proteins, they modulate interactions between cells and the cellular environment, regulate cell adhesion and
Choudhary, Anshoo +5 more
core +3 more sources
Thrombospondin production and thrombospondin-mediated adhesion in U937 cells [PDF]
Experimental Cell Research, 1991 U937 cells have low levels of surface thrombospondin (TSP) under control conditions but express higher levels after treatment for 1 day with 100 nM phorbol myristate acetate (PMA).
J. Varani +19 more
core +5 more sources
Nature Communications, 2019 Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function.
Tobias G. Schips +11 more
doaj +2 more sources
Emerging functions of thrombospondin-1 in immunity
Seminars in Cell and Developmental Biology, 2023 Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by interacting with components of the extracellular matrix and with several cell surface receptors.
Sukhbir Kaur, D. Roberts
semanticscholar +1 more source
TGF-β promotes microtube formation in glioblastoma through thrombospondin 1
bioRxiv, 2021 Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell communication structures promoting invasion and treatment resistance through network formation.
J. Joseph +32 more
semanticscholar +1 more source
Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis
Hepatology, 2021 NAFLD is the most common liver disease worldwide. NASH, the progressive form of NAFLD, and advanced fibrosis are associated with poor outcomes. We searched for their noninvasive biomarkers.
K. Kozumi +19 more
semanticscholar +1 more source
Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine
International Journal of Molecular Sciences, 2021 Recent advances provide evidence that the cellular signalling pathway comprising the ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range of diseases affecting renal, vascular, and metabolic function, as well as cancer.
Atharva Kale, N. Rogers, Kedar Ghimire
semanticscholar +1 more source
Cold Spring Harbor Perspectives in Biology, 2004 Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo transient or longer-term interactions with other extracellular matrix components. They share properties with other matrix molecules, cytokines, adaptor proteins, and chaperones, modulate the organization of collagen fibrils, and bind and localize an array of growth
Adams, JC, Lawler, J
openaire +5 more sources
Matrix Biology, 2022 PURPOSE Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum. Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of cancer cells.
K. Kitami +17 more
semanticscholar +1 more source
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance We propose a mechanism of matrix mechanotransduction initiated by thrombospondin-1 (Thbs1), connecting mechanical stimuli to Yes-associated protein (YAP) signaling during vascular remodeling.
Yoshito Yamashiro +9 more
semanticscholar +1 more source