Results 11 to 20 of about 78,453 (329)
Functions of Thrombospondin-1 in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 International audienceThe identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated
David D. Roberts +11 more
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Thrombospondin 1 in Metabolic Diseases
Frontiers in Endocrinology, 2021 The thrombospondin family comprises of five multifunctional glycoproteins, whose best-studied member is thrombospondin 1 (TSP1). This matricellular protein is a potent antiangiogenic agent that inhibits endothelial migration and proliferation, and ...
Linda S. Gutierrez, Jovita Gutierrez
doaj +2 more sources
THBS1 (thrombospondin-1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020 Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncogenes and ...
Isenberg, Jeffrey S, Roberts, David D
core +4 more sources
Thrombospondins: Purification of human platelet thrombospondin-1 [PDF]
Methods in Cell Biology, 2018 Thrombospondins are a family of five secreted proteins that have diverse roles in modulating cellular function. Thrombospondins-1 and 2 were identified as matricellular proteins based on their functional roles combined with their transient appearance or accumulation in extracellular matrix at specific times during development and in response to injury ...
John M, Sipes +2 more
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Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review)
International Journal of Molecular Medicine, 2020 Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). The multiple effects of TSP‑1 and TSP‑2 are due to their ability to interact with various ligands, such as structural components of the ECM, cytokines ...
Zhang, Kaijie +4 more
openaire +4 more sources
E2F-1 directly regulates thrombospondin 1 expression. [PDF]
PLoS ONE, 2010 Thrombospondin 1 (TSP1) has been shown to play a critical role in inhibiting angiogenesis, resulting in inhibition of tumor growth and metastases. To figure out TSP1's regulators will lead to reveal its biological function mechanistically. In this study,
Wei Ji, Wei Zhang, Wuhan Xiao
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Science Signaling, 2018 Fibrillar collagens of the extracellular matrix are critical for tissue structure and physiology; however, excessive or abnormal deposition of collagens is a defining feature of fibrosis.
Arkadiusz M. Bonna (16660719) +5 more
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Türk Biyokimya Dergisi, 2023 Roles of thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear.
Dogan Serdar +4 more
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Thrombospondin expression in myofibers stabilizes muscle membranes
eLife, 2016 Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy.
Davy Vanhoutte +13 more
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Mammalian Genome, 1999 Thrombospondins are a family of extracellular, adhesive proteins that are widely expressed in vertebrates. Five distinct gene products, designated thrombospondin-1 through -4 and cartilage oligomeric matrix protein (COMP), have been identified.
Gilbert, D J +6 more
core +5 more sources