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Pathogenesis of Thrombotic Microangiopathies [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2007
Profound thrombocytopenia and microangiopathic hemolytic anemia characterize thrombotic microangiopathy, which includes two major disorders: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). TTP has at least three types: congenital or familial, idiopathic, and nonidiopathic.
X Long, Zheng, J Evan, Sadler
openaire   +2 more sources

Long-Term Survival Following Nivolumab Treatment in Pulmonary Tumour Thrombotic Microangiopathy Associated With Cancer of Unknown Primary: A Case Report. [PDF]

Respirol Case Rep
Pulmonary tumour thrombotic microangiopathy (PTTM) is a rapidly fatal condition that is rarely diagnosed during life. Early clinical recognition and prompt nivolumab treatment resulted in long‐term survival in a patient with cancer of unknown primary‐associated PTTM.
Fujishima K, Osugi J, Noma S, Higuchi M, Suzuki H.   +4 more
europepmc   +2 more sources

Perindopril/amlodipine-induced thrombotic microangiopathy

Turkish Journal of Emergency Medicine, 2021
This is the first report on a case of perindopril/amlodipine-induced thrombotic microangiopathy (TMA) syndrome. A 48-year-old female was admitted complaining of nettle rash all over the body, bloody urine, and weakness shortly after starting ...
Vlatka Perisa, Dorian Laslo, Lana Maričć, Lada Zibar   +3 more
doaj   +1 more source

Carfilzomib-Induced Thrombotic Microangiopathy: Focus on Pathogenesis

, 2022
Drug-induced thrombotic microangiopathies present in similar fashion but have varied pathogenic mechanisms. Carfilzomib is an irreversible proteasome inhibitor.
Hermelin, Daniela, Blackall, Douglas, Eigbire-Molen, Odianosen   +2 more
core   +2 more sources

The PLASMIC Score May Be Useful in the Early Diagnosis of Complement-Mediated Thrombotic Microangiopathy via Early Exclusion of Thrombotic Thrombocytopenic Purpura

Case Reports in Medicine, 2019
Complement-mediated thrombotic microangiopathy is a rare form of thrombotic microangiopathy but has high rates of mortality and morbidity. Effective treatment exists with eculizumab for this condition, but administration of treatment is often delayed ...
Edwin Lu, Willie Moore
doaj   +1 more source

Post-traumatic thrombotic microangiopathy following pelvic fracture treated with transcatheter arterial embolization: a case report

Journal of Medical Case Reports, 2018
Background Thrombotic microangiopathy is caused by various conditions, but few cases secondary to trauma have been reported. We present the rare case of a patient with thrombotic microangiopathy-induced high-impact trauma with hemorrhagic shock.
Kaori Ikegami, Takuma Yamagishi, Junya Tajima, Yukinori Inoue, Ken Kumagai, Yasuo Hirose, Daisuke Kondo, Koji Nikkuni   +7 more
doaj   +1 more source

Thrombotic Microangiopathy and the Kidney [PDF]

Clinical Journal of the American Society of Nephrology, 2017
Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases ...
Brocklebank V, Wood KM, Kavanagh D
openaire   +3 more sources

Potential Benefit of Ruxolitinib in Suspected Ocular and Neurological Transplant-Associated Thrombotic Microangiopathy After Allogeneic Stem Cell Transplantation: A Case Report and Review. [PDF]

Clin Case Rep
ABSTRACT We describe a rare case of suspected delayed‐onset TA‐TMA with ocular and neurological involvement following allo‐HSCT. The condition was refractory to standard therapies; neurological improvement was temporally associated with ruxolitinib initiation, suggesting a possible GVHD overlap.
Pillet LM, Arandilla A, Sauvetre G, Goupillou P, Lefevre A, Grall M, Bonnevalle A, Bourre B, Penther D, Porcheron S, Jardin F, Alani M, Dubois S, Camus V.   +13 more
europepmc   +2 more sources

Transplant-associated thrombotic microangiopathy

Pediatria Polska, 2021
Transplant-associated thrombotic microangiopathy (TA-TMA), which is a severe and quite frequent complication of hematopoietic stem cell transplantation (HSCT) in children, significantly influences patients’ overall survival.
Tomasz Jarmoliński
doaj   +1 more source

Characteristics and management of thrombotic microangiopathy in kidney transplantation

Korean Journal of Transplantation, 2023
Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries.
Wonyong Cho, Sang-Kyung Jo, Cheol Woong Jung, Myung-Gyu Kim   +3 more
doaj   +1 more source