Results 111 to 120 of about 47,275 (224)
Thromboxane stimulates synthesis of extracellular matrix proteins in vitro
, 1991 The vasoconstrictor eicosanoid thromboxane plays an important role in the pathogenesis of several renal diseases. As an autacoid, its local release alters blood flow and induces platelet aggregation.
P. E. Ray +4 more
core +1 more source
LifeMetabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also an independent risk factor for the development of cardiovascular ...
Andrea Boccatonda +10 more
doaj +1 more source
Synthetic approaches to thromboxane B2 [PDF]
, 1981 The first part of this thesis consists of a review concerning recent progress in the synthesis of thromboxane B2. Mention is also made of the synthesis of related compounds and precursors, i.e.
Hutcheson, John McMurray
core
From the design to the clinical application of thromboxane modulators
, 2006 peer reviewedArachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of particular importance is thromboxane A(2)
Pace-Asciak, Cecil R +8 more
core +1 more source
Inhibiting breast cancer by targeting the thromboxane A2 pathway
, 2017 Targeting the estrogen receptor as a strategy has been the gold standard for breast cancer chemoprevention or breast cancer recurrence, but its benefit is limited to estrogen receptor-positive tumors.
Ann M. Bode +13 more
core +1 more source
Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling
, 2015 In 1975, Hamberg and associates [1] discovered that human platelets transform arachidonic acid into prostaglandin endoperoxides then further into thromboxane B₂ through the unstable intermediate thromboxane A₂. Pinane thromboxane A₂ is a stable analog of
Grenke, Holly
core +1 more source
Serum thromboxane generation by platelets in several domestic animal species
, 1990 Blood collected from calves, sheep, goats, pigs, dogs, horses, ponies and donkeys, was allowed to clot under standard conditions. Thromboxane B2 generated during the clotting process was measured by radioimmunoassay in serum harvested from each sample ...
Nolan, A. M. +2 more
core +1 more source
Thromboxane A2-Driven Vascular Hyperreactivity in Cadmium-Induced Hypertension: Role of Oxidative Stress and Therapeutic Implications. [PDF]
J Clin MedGarcía-González MA +9 more
europepmc +1 more source