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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes [PDF]
Journal of Clinical Investigation, 2001 Virtually every organism has evolved mechanisms by which, upon stimulation, lipids are released from plasma membranes and metabolized into mediators capable of changing cellular physiology.
Beverly Koller, Stephen L Tilley
exaly +2 more sources
Journal of Chromatography A, 2009 Udgivelsesdato: 2009-May-29An on-line strong cation-exchange (SCX)-reversed-phase (RP) capillary liquid chromatographic (cLC) method with ion-trap tandem mass spectrometric (IT-MS/MS) detection for the simultaneous determination of thromboxane (TX) B(2),
Tor Lea, Elsa Lundanes
exaly +2 more sources
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PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS
Pharmacology & Therapeutics, 1991We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We discuss the three major steps in prostanoid formation: (a) arachidonate mobilization from monophosphatidylinositol involving phospholipase C, diglyceride ...
W L, Smith, L J, Marnett, D L, DeWitt
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Leukotriene and thromboxane antagonists
Clinical Reviews in Allergy, 1994It has been suggested that arachidonate metabolites, leukotrienes, and thromboxane may play important roles in the pathogenesis of bronchial asthma. Biologic activities of these mediators are much more potent than those of histamine and acetylcholine on a molar basis in inducing bronchoconstriction, increase in microvascular permeability, formation of ...
T, Obata, N, Yamashita, T, Nakagawa
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A radioimmunoassay for thromboxane B2
Analytical Biochemistry, 1977Abstract Thromboxane B 2 levels are believed to reflect the levels of the active precursor thromboxane A 2 , present during biosynthetic transformations of arachidonic acid. A radioimmunoassay for thromboxane B 2 is described. The antibodies show selective recognition of the thromboxane B structure with a sensitivity of 100 pg.
F A, Fitzpatrick +5 more
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Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion
Journal of Molecular Medicine, 2010Thromboxane A(2) (TXA(2)) is a potent prothrombotic and immune modulating lipid mediator, which is implicated in cardiovascular diseases, in particular, atherosclerotic lesion development and thrombogenicity. Here, we tested the hypothesis that thromboxane synthase (TXAS), the obligate enzyme required to synthesize TXA(2), is expressed within the human
Anders, Gabrielsen +11 more
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Anti-thromboxane A2 actions of pinane thromboxane A2 derivatives
Prostaglandins, Leukotrienes and Medicine, 1982Six pinane-thromboxane A2 analogs have been synthesized and tested for their ability to antagonize carbocyclic thromboxane A2 (CTA2) induced coronary vasoconstriction and prostaglandin endoperoxide analog induced platelet aggregation. Two of the derivatives, 5C-15S BPTA2 and 5T-15S BPTA2 and 5T-15S BPTA2 (1 microM) showed 76 +/- 3 and 72 +/- 9 percent ...
D M, Roth +3 more
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Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade
Vascular Pharmacology, 2004Because sulfonylureas, such as glibenclamide, are used to treat Type 2 diabetes and because this disease is associated with various cardiovascular complications that may be mediated by thromboxane (TX), this study was designed to characterize the role of glibenclamide on TX-mediated contractions in isolated ring segments of bovine coronary arteries and
Sandra L, Pfister +3 more
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