Results 201 to 210 of about 9,969 (239)
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Prostaglandins, 1986
The metabolism of thromboxane B2 was studied in the rabbit. The aim of the study was to identify metabolites in blood and urine that might serve as parameters for monitoring thromboxane production in vivo. [5,6,8,9,11,12,14,15-3H8]-Thromboxane B2 was administered by i.v.
P, Westlund +3 more
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The metabolism of thromboxane B2 was studied in the rabbit. The aim of the study was to identify metabolites in blood and urine that might serve as parameters for monitoring thromboxane production in vivo. [5,6,8,9,11,12,14,15-3H8]-Thromboxane B2 was administered by i.v.
P, Westlund +3 more
openaire +2 more sources
CONGENITAL DEFICIENCY OF THROMBOXANE AND PROSTACYCLIN
The Lancet, 1980Animal work suggests that with certain doses of aspirin the antithrombotic effect exerted via the inhibition of the proaggregatory platelet thromboxane A2 (TXA2) may be neutralised by the concomitant vascular reduction of the antiaggregatory prostacyclin (PGI2).
PARETI F.I. +5 more
openaire +3 more sources
1985
When platelets are stimulated to aggregate and secrete by a sub-maximal concentration of an agonist, the platelets on the outside of an aggregate appear more degranulated than those on the inside (1) (fig. 1). In the example shown, aggregation of rabbit platelet-rich plasma (PRP) was induced by a sub-maximal concentration of collagen.
J, Ambler +3 more
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When platelets are stimulated to aggregate and secrete by a sub-maximal concentration of an agonist, the platelets on the outside of an aggregate appear more degranulated than those on the inside (1) (fig. 1). In the example shown, aggregation of rabbit platelet-rich plasma (PRP) was induced by a sub-maximal concentration of collagen.
J, Ambler +3 more
openaire +2 more sources
Prostaglandins and Thromboxane
Critical Care Clinics, 1985This article attempts to delineate the role of the prostanoids in thermal injury, based on clinical and experimental trials. It also describes the authors’ concept of the cause of progressive dermal ischemia in the thermal injury and possible therapeutic measures to prevent or reduce this detrimental effect.
John P. Heggers, Martin C. Robson
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New Developments on Thromboxane Modulators
Mini-Reviews in Medicinal Chemistry, 2004Thromboxane A(2) (TXA(2)) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA(2) modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA(2) modulators.
Dogné, Jean-Michel +5 more
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Circulation, 1995
The age-dependent increase in death from cardiovascular disease is less pronounced in premenopausal women than in men, but this divergence of risk narrows after middle age.1 This results from a relative increase in the death rate in women after the menopause.2 It has been suggested that the immediate postmyocardial infarction death rate is higher in ...
Domenico Pratico, Garret A. FitzGerald
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The age-dependent increase in death from cardiovascular disease is less pronounced in premenopausal women than in men, but this divergence of risk narrows after middle age.1 This results from a relative increase in the death rate in women after the menopause.2 It has been suggested that the immediate postmyocardial infarction death rate is higher in ...
Domenico Pratico, Garret A. FitzGerald
openaire +1 more source
1995
This chapter defines thromboxane A2 as a naturally occurring substance that has the undesirable effects of bronchoconstriction, aggregation of the blood platelets, and constriction of the blood vessels whenever it is released in the body. The inhibition of the effects of thromboxane A2 could lead to a potential treatment for circulatory or respiratory ...
Stan Lee, Graham Robinson
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This chapter defines thromboxane A2 as a naturally occurring substance that has the undesirable effects of bronchoconstriction, aggregation of the blood platelets, and constriction of the blood vessels whenever it is released in the body. The inhibition of the effects of thromboxane A2 could lead to a potential treatment for circulatory or respiratory ...
Stan Lee, Graham Robinson
openaire +1 more source
Prostacyclin and thromboxane synthases
Journal of Lipid Mediators and Cell Signalling, 1995T, Tanabe, V, Ullrich
openaire +2 more sources