Results 131 to 140 of about 1,985,368 (271)

Screening for molecular glues – Challenges and opportunities

open access: yesSLAS Discovery
Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical properties that aim to stabilise the interaction between two proteins.
Geoffrey A. Holdgate   +4 more
doaj  

PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1

open access: yesNature Communications
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The yeast histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance its ability to ...
Wenjing Dai   +10 more
doaj   +1 more source

High throughput screening of tubulin inhibitors from parasitic fungi

open access: gold, 1970
П. А. Карпов   +6 more
openalex   +2 more sources

Clinical impact of IDH1 mutations and MGMT methylation in adult glioblastoma

open access: yesEgyptian Journal of Medical Human Genetics
Background Impact of Isocitrate dehydrogenase1 (IDH1) and O6-methylguanine-DNA methyltransferase (MGMT) in glioblastoma (GBM) have been of great interest due to their implications in prediction of prognosis of several types of cancer.
Magda Sayed Mahmoud   +8 more
doaj   +1 more source

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